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Article
Virtual prototy** for workplace analysis: the effect of expectation on perceived comfort while using office devices
Computer aided technologies (CAT) are becoming an indispensable instrument to design, improve and manufacture new products and services. Digital human modelling (DHM) systems allow to simulate the Human-artifa...
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Article
Open AccessExpert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) such as gefitinib, erlotinib, and afatinib are standard-of-care for first-line treatment of EGFR-mutant advanced non-small cell lung ca...
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Article
Open AccessA phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours
Poly adenosine diphosphate (ADP)-ribose polymerase (PARP) is essential in cellular processing of DNA damage via the base excision repair pathway (BER). The PARP inhibition can be directly cytotoxic to tumour c...
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Article
Open AccessPhase III randomised trial of doxorubicin-based chemotherapy compared with platinum-based chemotherapy in small-cell lung cancer
This randomised trial compared platinum-based to anthracycline-based chemotherapy in patients with small-cell lung cancer (limited or extensive stage) and ⩽2 adverse prognostic factors. Patients were randomise...
