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Article
Euglycaemic hyperinsulinaemia does not affect gastric emptying in Type I and Type II diabetes mellitus
Hyperglycaemia slows gastric emptying in both normal subjects and patients with diabetes mellitus. The mechanisms mediating this effect, particularly the potential role of insulin, are uncertain. Hyperinsulin...
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Article
The effect of single doses of pramlintide on gastric emptying of two meals in men with IDDM
In a previous study we have shown that an intravenous infusion of pramlintide (an analogue of human amylin) delayed gastric emptying, but the dose of pramlintide was supraphysiological in relation to the amyl...
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Article
Effect of euglycaemic hyperinsulinaemia on gastric emptying and gastrointestinal hormone responses in normal subjects
Several studies have shown that hyperglycaemia slows gastric emptying in normal subjects and patients with diabetes mellitus but whether hyperinsulinaemia per se has an effect remains debatable. In the presen...
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Article
Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM
Pramlintide, a human amylin analogue, reduces hyperglycaemia after meals in patients with insulin-dependent diabetes mellitus (IDDM). We investigated whether this was due to delayed gastric emptying. Eight me...
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Article
Physiological response to postural change during mild hypoglycaemia in patients with IDDM
It has been suggested that patients with insulin-dependent diabetes mellitus may be less aware of impending hypoglycaemia when lying than standing. We have studied the effect of posture and duration of hypogly...
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Article
Thermoregulatory responses to hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM
In healthy subjects hypoglycaemia causes a fall in body temperature through increased sweating and limb blood flow, and despite increased metabolic heat production. We studied thermoregulatory responses to hyp...
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Article
Book reviews
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Article
Alcohol causes hypoglycaemic unawareness in healthy volunteers and patients with Type 1 (insulin-dependent) diabetes
Both hypoglycaemia and alcohol consumption affect cognitive function but it is unclear whether moderate drinking alters awareness of hypoglycaemia. We have examined this in a single blind randomised hyperinsul...
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Article
Adaptation to mild hypoglycaemia in normal subjects despite sustained increases in counter-regulatory hormones
In diabetes, loss of awareness of and a defective hormonal response to hypoglycaemia have been associated with long disease duration, improved glycaemic control and possibly a change in insulin species. In con...
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Article
Book review
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Article
Counterregulation in Type 2 (non-insulin-dependent) diabetes mellitus. Normal endocrine and glycaemic responses, up to ten years after diagnosis
We have examined hormonal and metabolic responses to insulin-induced hypoglycaemia in 10 Type 2 (non-insulin-dependent) diabetic patients treated with tablets and 10 age, sex and weight matched control subject...
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Chapter
Genetic counselling in Diabetes Mellitus
My impression (probably wrong) is that professional genetics are more often asked to advise about rare but serious diseases, especially those with onset in infancy, than about common conditions like diabetes w...
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Article
Immunogenicity of highly purified bovine insulin: a comparison with conventional bovine and highly purified human insulins
Twenty-six Type 1 diabetic patients previously treated for 10–20 months with twice daily conventional bovine isophane insulin (containing at least 1000 ppm proinsulin) were changed to highly purified (<1 ppm p...
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Article
A prospective comparison of ‘conventional’ and high carbohydrate / high fibre / low fat diets in adults with established Type 1 (insulin-dependent) diabetes
Diabetic associations throughout the world are recommending high carbohydrate / high fibre / low fat diets for diabetic patients as a means of improving general health and metabolic control. We have previously...
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Article
Diabetes in the elderly — a neglected area?
My intention has been to suggest that there are enough subtle differences between diabetes in the old and that in young to make management of the former a speciality in its own right. Elderly patients with dia...
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Article
Factors governing the human immune response to injected insulin
Seventy-nine patients were observed prospectively during their initial period of treatment with conventional bovine insulins. Insulin antibody levels 6 months after starting insulin therapy did not correlate w...
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Article
Book reviews
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Article
Severely uncontrolled diabetes in the over-fifties
Between 1969 and 1976, 317 adults were admitted to hospital in Nottingham with severely uncontrolled diabetes (plasma glucose over 33 mmol/l and/or venous bicarbonate less than 14 mmol/l). A third of episodes ...
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Article
Diabetes in adolescence
The adolescent diabetic has a totally different set of problems from either the child or adult with diabetes. Failure to recognise this and deal with it will result in non-compliance and non-attendance at the ...
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Article
Book reviews
