-
Article
The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer
Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared wi...
-
Article
Transforming Growth Factor-Beta Signaling Leads to uPA/PAI-1 Activation and Metastasis: A Study on Human Breast Cancer Tissues
Metastasis represents a major problem in the treatment of patients with advanced primary breast cancer. Both Transforming Growth Factor-Beta (TGF-β) signaling and Plasminogen Activator (PA) components, urokina...
-
Article
Open AccessCXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
Adoptive therapy with tumour-infiltrating lymphocytes (TILs) induces durable complete responses (CR) in ∼20% of patients with metastatic melanoma. The recruitment of T cells through CXCR3/CCR5 chemokine ligand...
-
Article
Open AccessPresence of the Coxsackievirus and Adenovirus Receptor (CAR) in human neoplasms: a multitumour array analysis
The Coxsackie- and Adenovirus Receptor (CAR) has been assigned two crucial attributes in carcinomas: (a) involvement in the regulation of growth and dissemination and (b) binding for potentially therapeutic ad...
-
Article
Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer
AIB1 (amplified in breast cancer 1) is an estrogen receptorα (ERα) co-activator, known to be amplified and overexpressed in a fraction of breast cancers. It has been linked to prognosis and tamoxifen resistance. ...
-
Article
Open AccessKRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma...
-
Article
Expression of TGF-β receptor ALK-5 has a negative impact on outcome of patients with acute myeloid leukemia
-
Article
Gene amplification in ductal carcinoma in situ of the breast
Multiple different biologically and clinically relevant genes are often amplified in invasive breast cancer, including HER2, ESR1, CCND1, and MYC. So far, little is known about their role in tumor progression....
-
Article
Open AccessDysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer
The aim of this study was to identify deregulated transcription factors (TFs) in colorectal cancer (CRC) and to evaluate their relation with the recurrence of stage II CRC and overall survival. Microarray-base...
-
Article
Reelin expression in breast tumours is associated with increased survival and is controlled by promoter methylation
-
Article
Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma
Oncogenic wingless-related mouse mammary tumour virus (Wnt) signalling, caused by epigenetic inactivation of specific pathway regulators like the putative tumour suppressor secreted frizzled-related protein 1 ...
-
Article
KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer
Molecular mechanisms of prostate cancer progression are poorly understood. Here, we studied gene amplification of the large conductance calcium-activated potassium channel alpha subunit (KCNMA1), which is located...
-
Article
E2F3 is the main target gene of the 6p22 amplicon with high specificity for human bladder cancer
Amplification of 6p22 occurs in about 10–20% of bladder cancers and is associated with enhanced tumour cell proliferation. Candidate target genes for the 6p22 amplicon include E2F3 and the adjacent gene ...
-
Article
Use of genomic signatures in therapeutics development in oncology and other diseases
Pharmacogenomics is the science of determining how the benefits and adverse effects of a drug vary among a target population of patients based on genomic features of the patient's germ line and diseased tissue...
-
Article
Designing prospective clinical pharmacogenomic (PG) trials: meeting report on drug development strategies to enhance therapeutic decision making
-
Article
Open AccessFrequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers
Epithelial cell adhesion molecule (Ep-CAM; CD326) is used as a target by many immunotherapeutic approaches, but little data are available about Ep-CAM expression in major human malignancies with respect to lev...
-
Article
Open AccessDiagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data
DNA microarrays are a potentially powerful technology for improving diagnostic classification, treatment selection and therapeutics development. There are, however, many potential pitfalls in the use of microa...
-
Article
Open AccessIdentifying pre-post chemotherapy differences in gene expression in breast tumours: a statistical method appropriate for this aim
Although widely used for the analysis of gene expression microarray data, cluster analysis may not be the most appropriate statistical technique for some study aims. We demonstrate this by considering a previo...
-
Article
Molekulare Ursachen der Tumorentstehung
-
Article
Molekularbiologie maligner Tumorerkrankungen
