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Article
Chronic, including teratogenic and carcinogenic effects of trichothecenes: A short review
Trichothecenes are toxic sesquiterpenes, produced as secondary metabolites by certain soil microfungi in agricultural products harvested during wet and cold weather, and/or stored inappropriately. When present...
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Chapter and Conference Paper
Mycotoxins in Food
Microfungi are almost ubiquitous. Fortunately not all produce toxic or otherwise deleterious secondary metabolites, known as mycotoxins.
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Article
Variation in the incidence of “spontaneous” tumours
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Article
Irreversible depigmentation of dark mouse hair by T-2 toxin (a metabolite ofFusarium sporotrichioides) and by calcium pantothenate
T-2 toxin, a trichothecene metabolite of several Fusarium spp. causes depigmentation of dark mouse hair at the site of its application. Calcium pantothenate, though usually considered as antigreying factor, ca...
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Article
Induction of tumours and bifunctional crosslinking metabolites of nitrosamines
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Article
Chromium carcinogenesis, formation of epoxyaldehydes and tanning
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Article
Proceedings: Is alkylation of nicotinamide the cause of liver necrosis that follows large doses of hepatocarcinogens?
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Article
Proceedings: Chromium carcinogenesis and glycidal formation
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Article
Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide
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Article
Carcinogens in Rat Milk
Mothers of 5-day old rats were given diethylnitrosamine (DEN) (130 mg/kg body weight) by stomach tube. The milk removed from the stomachs of the suckling young contained 5, 16 and 36 parts/106 of DEN at 2, 4 and ...
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Article
Proceedings: Zearalenone in the diet, podophyllotoxin in the wood shavings bedding, are likely to affect the incidence of "spontaneous" tumours among laboratory animals
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Article
The mode of action of carcinogens which can induce tumours with a single dose: a new hypothesis
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Article
The Mechanisms of Action of the Carcinogenic Nitroso and Related Compounds
It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega o...
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Article
The development of tumours in a female rat and her offspring, following administration of diethylnitrosamine to the mother during nursing
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Article
Nasal and other tumours in rats given 3,4,5-trimethoxy-cinnamaldehyde, a derivative of sinapaldehyde and of other α,β-unsaturated aldehydic wood lignin constituents
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Article
Herbal Medicines to Avoid
IN East Africa, certain rare tumours, oesophageal, nasopharyngeal, liver, Burkitt lymphomas and the like, are concentrated in distinct localized pockets1. The reason for this and the aetiology of these tumours ar...
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Article
Irreversible depigmentation of hair by N-methyl-N-nitrosourethane
Une injection du carcinogène N-méthyl-N-nitrosouréthane (MNU) entraine dépigmentation permanente des poils des animaux pigmentés (ceux des souris CBA et des oreilles du lapin «Dutch»). Le rôle des groupements ...
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Article
Hepatotoxic Activity of Retrorsine, Senkirkine and Hydroxysenkirkine in Newborn Rats, and the Role of Epoxides in Carcinogenesis by Pyrrolizidine Alkaloids and Aflatoxins
NEWBORN rats have proved strikingly more susceptible than weanlings to the hepatotoxic action of a single dose of the hepatocarcinogen retrorsine, and also to senkirkine and hydroxysenkirkine (cyclic diesters ...
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Article
Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine.
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Article
Carcinogenic Action of Elaiomycin in Rats
SEVERAL natural products of plant or microbial origin have been discovered in the past 20 yr that have proved carcinogenic in experimental animals1. These products include certain pyrrolizidine alkaloids, luteosk...
