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  1. No Access

    Article

    Cognitive Decline and Modulation of Alzheimer’s Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons

    MicroRNAs have emerged as regulators of brain development and function. Reduction of miR-101 expression has been reported in rodent hippocampus during ageing, in the brain of Alzheimer’s disease (AD) patients ...

    C. Barbato, G. Giacovazzo, F. Albiero, R. Scardigli, C. Scopa… in Molecular Neurobiology (2020)

  2. Article

    ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

    ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioact...

    C Tiveron, L Fasulo, S Capsoni, F Malerba, S Marinelli… in Cell Death & Differentiation (2013)

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    Article

    Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging

    Some gene therapy approaches for cancer treatment attempt to transduce onco-suppressor genes into tumor cells. A central problem of this strategy is the targeting of tumor cells to avoid damage to normal ones....

    R Scardigli, G Bossi, G Blandino, M Crescenzi, S Soddu, A Sacchi in Gene Therapy (1997)