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Article
High dose chemotherapy and autologous bone marrow transplantation in refractory Hodgkin's disease
Seventeen patients with Hodgkin's disease (HD) were treated with high-dose chemotherapy followed by autologous bone marrow transplantation (ABMT). Eleven patients were resistant to initial therapy. Three patie...
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Chapter and Conference Paper
Autologous Bone Marrow Transplantation in Paediatric Solid Tumours
In leukaemia allogeneic bone marrow transplantation is a method by which high-dose, often curative therapy can be given without regard to marrow toxicity. Applying the same principle to paediatric solid tumour...
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Chapter
Neuroblastoma
Neuroblastoma is the second most common solid childhood tumor and the outlook for patients with limited disease (25% of the cases) is good. However, with more advanced or metastatic disease, complex and demand...
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Chapter
Very High Dose Therapy in Lymphomas and Solid Tumors
Allogenic bone marrow transplantation is now a major treatment in hematology both for severe aplastic anemia and following intensive chemoradiotherapy regimens for chronic myeloid leukemia, high-risk acute lym...
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Article
High-dose cytosine arabinoside plus etoposide as initial treatment for acute myeloid leukaemia: a single centre study
In a single centre, 52 newly diagnosed patients with acute myeloid leukemia (AML) under the age of 56 years received induction chemotherapy commencing with high-dose cytosine arabinoside (Ara-C) and etoposide ...
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Article
Outcome of children with resistant and relapsed Hodgkin's disease
During the period 1974-89, 169 children with Hodgkin's disease were treated in the Paediatric Oncology Units of the Royal Marsden and St Bartholomew's Hospitals. The overall actuarial survival for the whole gr...
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Article
Double megatherapy and autologous bone marrow transplantation for advanced neuroblastoma: the LMCE2 study
In the LMCE1 study using a single course of megatherapy most of the relapses occurred during the first 2 years after autologous bone marrow transplantation. A second pilot study (LMCE2) was therefore set up us...
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Article
CHILDHOOD BIPHENOTYPIC LEUKAEMIA : THE ROYAL MARSDEN EXPERIENCE. 160
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Article
Melphalan/TBI is not more carcinogenic than cyclophosphamide/TBI for transplant conditioning: follow-up of 725 patients from a single centre over a period of 26 years
As there is concern regarding the high carcinogenic potential of melphalan (Mel), 725 patients with haematological malignancies who received allogeneic (n = 714) or syngeneic (n = 11) transplants over the last 26...
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Article
Open AccessSOR: project methodology
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Article
Open AccessDetection of the PAX3-FKHR fusion gene in paediatric rhabdomyosarcoma: a reproducible predictor of outcome?
Rhabdomyosarcoma has 2 major histological subtypes, embryonal and alveolar. Alveolar histology is associated with the fusion genes PAX3-FKHR and PAX7-FKHR. Definition of alveolar has been complicated by changes i...
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Article
Medical students' perceptions of sexual health issues prior to a curriculum enhancement
The objectives were to compare first, second and third year medical students on self-perceived sexual health knowledge, comfort in addressing sexual health problems, and attitudes towards the importance of add...
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Article
Open AccessA phase I study of intravenous liposomal daunorubicin (DaunoXome) in paediatric patients with relapsed or resistant solid tumours
Anthracyclines are widely used in paediatric oncology, but their use is limited by the risk of cumulative cardiac toxicity. Encapsulating anthracyclines in liposomes may reduce cardiac toxicity and possibly in...
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Reference Work Entry In depth
DALYs and Diarrhea
Burden of disease assessments must incorporate both years of life lost and years lost to disability. This is especially important for diseases that have long-term effects in addition to early life mortality. S...
