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  1. Article

    Open Access

    DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer

    Bisphenol A (BPA), an estrogen-like endocrine disruptor used in plastics, has been associated with development and promotion of breast cancer, so plastic manufacturers shifted towards less-studied analogs, BPF...

    Z. Awada, R. Nasr, R. Akika, V. Cahais, C. Cuenin, M. Zhivagui… in Clinical Epigenetics (2019)

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  2. No Access

    Article

    (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo

    The vitamin E derivative (+)α-tocopheryl succinate (α-TOS) exerts pro-apoptotic effects in a wide range of tumors and is well tolerated by normal tissues. Previous studies point to a mitochondrial involvement ...

    G A S dos Santos, R S Abreu e Lima, C R Pestana, A S G Lima, P S Scheucher… in Leukemia (2012)

  3. No Access

    Article

    Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome

    Constitutive activation of the NF-κB pathway by the Tax oncoprotein plays a crucial role in the proliferation and transformation of HTLV-I infected T lymphocytes. We have previously shown that Tax ubiquitylati...

    Y Kfoury, R Nasr, A Favre-Bonvin, M El-Sabban, N Renault, M-L Giron… in Oncogene (2008)

  4. Article

    Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-κB pathway

    Y Kfoury, R Nasr, O Hermine, H de Thé, A Bazarbachi in Cell Death & Differentiation (2005)

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  5. No Access

    Article

    N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in HTLV-I-transformed cells

    N-(4-hydroxyphenyl)retinamide (HPR) is a synthetic retinoid that inhibits growth and induces apoptosis in many human cell lines. We explored the effects of HPR on human T-cell lymphotropic virus type I (HTLV-I).....

    N Darwiche, A Hatoum, G Dbaibo, H Kadara, R Nasr, G Abou-Lteif, R Bazzi… in Leukemia (2004)

  6. No Access

    Article

    Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma

    The combination of the anti-viral agents, zidovudine (AZT) and interferon-α (IFN), is a potent treatment of HTLV-I-associated adult T cell leukemia/lymphoma (ATL). In this study we investigate the possible mec...

    A Bazarbachi, R Nasr, ME El-Sabban, A Mahé, R Mahieux, A Gessain, N Darwiche… in Leukemia (2000)