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    Article

    CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia

    Despite their apparently good prognosis ∼15% of high hyperdiploid (HD) childhood acute lymphoblastic leukemia (ALL) cases relapse. To search for responsible risk factors we determined copy number aberrations a...

    A Inthal, P Zeitlhofer, M Zeginigg, M Morak, R Grausenburger, E Fronkova… in Leukemia (2012)

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    Article

    Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts

    The ETV6/RUNX1 (E/R) gene fusion is generated by the t(12;21) and found in approximately 25% of childhood B-cell precursor acute lymphoblastic leukemia. In contrast to the overwhelming evidence that E/R is critic...

    G Fuka, H-P Kantner, R Grausenburger, A Inthal, E Bauer, G Krapf, U Kaindl… in Leukemia (2012)