11 Result(s)

Article

Clonal mast cell disease not meeting WHO criteria for diagnosis of mastocytosis: clinicopathologic features and comparison with indolent mastocytosis

A Pardanani, D Chen, R A Abdelrahman, K K Reichard, D Zblewski, A J Wood… in Leukemia (2013)

Article

A phase-2 trial of low-dose pomalidomide in myelofibrosis

In a previous study, we reported on the safety and efficacy of low-dose (0.5 mg) pomalidomide and prednisone and pomalidomide alone (2 mg/day), for the treatment of anemia associated with myelofibrosis (MF). T...

K H Begna, R A Mesa, A Pardanani, W J Hogan, M R Litzow, R F McClure, A Tefferi in Leukemia (2011)

Article

Recurrent IDH mutations in high-risk myelodysplastic syndrome or acute myeloid leukemia with isolated del(5q)

A Pardanani, M M Patnaik, T L Lasho, M Mai, R A Knudson, C Finke… in Leukemia (2010)

Article

IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms

Bone marrow DNA was screened for isocitrate dehydrogenase (IDH) mutations in 200 patients with chronic (n=166) or blast (n=34) phase myeloproliferative neoplasms (MPN). Included among the former were 77 patients ...

A Pardanani, T L Lasho, C M Finke, M Mai, R F McClure, A Tefferi in Leukemia (2010)

Article

Risk stratification for survival and leukemic transformation in essential thrombocythemia: a single institutional study of 605 patients

Unlike the case with thrombosis, prognostic models for survival and leukemic transformation (LT) in essential thrombocythemia (ET) are not available. Among 605 patients with ET seen at our institution and foll...

N Gangat, A P Wolanskyj, R F McClure, C-Y Li, S Schwager, W Wu, A Tefferi in Leukemia (2007)

Article

Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2

Detection of translocations involving MYC at 8q24.1 in B-cell lineage malignancies (BCL) is important for diagnostic and prognostic purposes. However, routine detection of MYC translocations is often hampered by ...

R R Einerson, M E Law, H E Blair, P J Kurtin, R F McClure, R P Ketterling… in Leukemia (2006)

Article

Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia

An activating point mutation in Janus kinase 2 (JAK2 V617F) was recently identified in myelofibrosis with myeloid metaplasia (MMM). To further elucidate the pathogenic significance, we examined the JAK2 mutati...

R A Mesa, A Tefferi, T S Lasho, D Loegering, R F McClure, H L Powell, N T Dai… in Leukemia (2006)

Article

JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained

Signal transducer and activator of transcription (STAT) proteins are phosphorylated and activated by Janus kinases (JAKs). Recently, several groups identified a recurrent somatic point mutation constitutively ...

D P Steensma, R F McClure, J E Karp, A Tefferi, T L Lasho, H L Powell… in Leukemia (2006)

Article

Validation of immunoglobulin gene rearrangement detection by PCR using commercially available BIOMED-2 primers

R F McClure, P Kaur, E Pagel, P D Ouillette, C E Holtegaard, C L Treptow… in Leukemia (2006)