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  1. No Access

    Article

    Acarbose related diarrhea: increased butyrate upregulates prostaglandin E

    The alpha-glucosidase inhibitor acarbose is a drug used to treat type II diabetes mellitus. It occasionally causes diarrhea. Acarbose related colitis has been reported. This note explains how such side effect...

    R. E. Kast in Inflammation Research (2002)

  2. No Access

    Article

    Aspirin, TNF-alpha, NFkB, and survival in multiple myeloma: the importance of measuring TNF-alpha

    Aspirin and other cyclooxygenase inhibitors can increase levels of tumor necrosis factor-alpha and engage pro-apoptosis paths and/or anti-apoptosis paths. Seemingly conflicting data are briefly reviewed. Aspir...

    R. E. Kast in InflammoPharmacology (2006)

  3. No Access

    Article

    Hyaluronate and risperidone for hemorrhagic cystitis

    D Focosi, R E Kast in Bone Marrow Transplantation (2007)

  4. No Access

    Article

    Melanoma inhibition by cyclooxygenase inhibitors

    Melanoma progression is often associated with supranormal levels of interleukin-6 (IL-6). Il-6 is an important growth factor for many cases of melanoma. A recent case report by Lejeune et al. [Melanoma Res 2006;1...

    R. E. Kast in Medical Oncology (2007)

  5. No Access

    Article

    Treatment schedules for 5-HT2A blocking in progressive multifocal leukoencephalopathy using risperidone or ziprasidone

    R E Kast, D Focosi, M Petrini, E L Altschuler in Bone Marrow Transplantation (2007)

  6. No Access

    Article

    Using blood brain barrier disruption by methamphetamine for drug delivery

    R. E. Kast in Journal of Neuro-Oncology (2007)

  7. No Access

    Article

    Central nervous system graft-versus-host disease: consider progressive multifocal leukoencephalopathy among the differential diagnoses

    D Focosi, R E Kast, F Maggi, S Galimberti, F Papineschi… in Bone Marrow Transplantation (2007)

  8. No Access

    Article

    How lithium treatment generates neutrophilia by enhancing phosphorylation of GSK-3, increasing HIF-1 levels and how this path is important during engraftment

    Lithium is commonly used in psychiatry for mood stabilization. Lithium treatment results in neutrophilia, increased platelets and increased circulating CD34+ haematopoietic stem cells, HSC. This paper outlines...

    R E Kast in Bone Marrow Transplantation (2008)

  9. No Access

    Article

    Use of FDA approved methamphetamine to allow adjunctive use of methylnaltrexone to mediate core anti-growth factor signaling effects in glioblastoma

    Methylnaltrexone (MNTX) was recently FDA approved to treat opiate induced constipation. It happens to also indirectly reduce Src activity. Src is a 54 kDa tyrosine kinase, crucial in signaling of, and link bet...

    R. E. Kast in Journal of Neuro-Oncology (2009)

  10. No Access

    Article

    Glioblastoma treatment using perphenazine to block the subventricular zone’s tumor trophic functions

    We present here a potential new treatment adjunct for glioblastoma. Building on murine studies, a series of papers appeared recently showing that therapeutic irradiation of the ipsilateral subventricular zone ...

    R. E. Kast, B. M. Ellingson, C. Marosi, M.-E. Halatsch in Journal of Neuro-Oncology (2014)

  11. Article

    Open Access

    Erlotinib augmentation with dapsone for rash mitigation and increased anti-cancer effectiveness

    The epidermal growth factor receptor tyrosine kinase inhibitor erlotinib has failed in many ways to be as potent in the anti-cancer role as pre-clinical studies would have suggested. This paper traces some asp...

    R. E. Kast in SpringerPlus (2015)

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  12. No Access

    Article

    Simultaneous Interference with HER1/EGFR and RAC1 Signaling Drives Cytostasis and Suppression of Survivin in Human Glioma Cells in Vitro

    We have previously reported that combined inhibition of the epidermal growth factor receptor by erlotinib and of RAC1 by NSC23766 yielded a synergistic antiproliferative effect on established and primary cultu...

    G. Karpel-Massler, M.-A. Westhoff, R. E. Kast, A. Dwucet… in Neurochemical Research (2017)