Skip to main content

7 Result(s)

within M.-A. Westhoff Remove this filter

and

  1. No Access

    Article

    Simultaneous Interference with HER1/EGFR and RAC1 Signaling Drives Cytostasis and Suppression of Survivin in Human Glioma Cells in Vitro

    We have previously reported that combined inhibition of the epidermal growth factor receptor by erlotinib and of RAC1 by NSC23766 yielded a synergistic antiproliferative effect on established and primary cultu...

    G. Karpel-Massler, M.-A. Westhoff, R. E. Kast, A. Dwucet… in Neurochemical Research (2017)

  2. Article

    Open Access

    KIT mutations in primary mediastinal B-cell lymphoma

    P D Nagel, A Stenzinger, F M Feld, M D Herrmann, S Brüderlein… in Blood Cancer Journal (2014)

    Download PDF (708 KB) View Article

  3. Article

    Open Access

    TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma

    Tumor necrosis factor α (TNFα) and other members of the TNF family affect adipose tissue metabolism and contribute to the obesity-related inflammation of adipose tissue. Here, we sought to identify the effects of...

    M Keuper, I Wernstedt Asterholm, P E Scherer, M-A Westhoff… in Cell Death & Disease (2013)

    Download PDF (1586 KB) View Article

  4. No Access

    Article

    The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair

    The failure of conventional therapies in glioblastoma (GBM) is largely due to an aberrant activity of survival cascades, such as PI3 kinase (PI3K)/Akt-mediated signaling. This study is the first to show that t...

    M -A Westhoff, J A Kandenwein, S Karl, S H K Vellanki, V Braun, A Eramo… in Oncogene (2009)

  5. No Access

    Article

    Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells

    The failure of malignant cells to undergo apoptosis is a major obstacle in cancer therapy, and thus identifying the underlining molecules involved therein is imperative for improving patient survival. An impor...

    M A Westhoff, S Zhou, M G Bachem, K M Debatin, S Fulda in Oncogene (2008)

  6. Article

    4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

    Apoptosis is a major mechanism of treatment-induced T-cell depletion in leukemia and autoimmune diseases. While ‘classical’ apoptosis is considered to depend on caspase activation, caspase-independent death is...

    G Strauss, M-A Westhoff, P Fischer-Posovszky, S Fulda… in Cell Death & Differentiation (2008)

    Download PDF (2963 KB) View Article

  7. No Access

    Article

    NF-κB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition

    The transcription factor nuclear factor-kappaB (NF-κB) is a key regulator of stress-induced transcriptional activation and has been implicated in mediating primary or acquired apoptosis resistance in various canc...

    K La Ferla-Brühl, M A Westhoff, S Karl, H Kasperczyk, R M Zwacka, K M Debatin… in Oncogene (2007)