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Article
Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer
Obesity promotes the development of insulin resistance and increases the incidence of colitis-associated cancer (CAC), but whether a blunted insulin action specifically in intestinal epithelial cells (IECs) af...
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Article
Open AccessZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells
During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately throu...
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Article
PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells
Oncoprotein C-MYC is overexpressed in human metastatic melanomas and melanoma-derived cells where it is required for the suppression of oncogene-induced senescence (OIS). The genetic events that maintain high ...
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Article
Negative regulation of Pim-1 protein kinase levels by the B56β subunit of PP2A
The Pim protein kinases are serine threonine protein kinases that regulate important cellular signaling pathway molecules, and enhance the ability of c-Myc to induce lymphomas. We demonstrate that a cascade of...
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Article
Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias
Overexpression of the c-Myc oncoprotein is observed in a large number of hematopoietic malignancies, and transgenic animal models have revealed a potent role for c-Myc in the generation of leukemias and lympho...
