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Article
Open AccessToxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study
Genetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem disorder in which immune dysfunction and infectious insults seem to play a major role in ...
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Article
Open AccessUse of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates
Rare variants may help to explain some of the missing heritability of complex diseases. Technological advances in next-generation sequencing give us the opportunity to test this hypothesis. We propose two new ...
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Article
Open AccessGenome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described.
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Article
Open AccessPower comparison of different methods to detect genetic effects and gene-environment interactions
Identifying gene-environment (G × E) interactions has become a crucial issue in the past decades. Different methods have been proposed to test for G × E interactions in the framework of linkage or association ...
