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Article
Open AccessThe industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1
The synthetic chemical 1,4-dioxane is used as industrial solvent, food, and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments and in humans, but ...
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Article
Open AccessAuthor Correction: TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain
In the originally published version of this Article, the affiliation details for Yan Wang, Yingwei Gao, Qi Deng, Yangbo Wang, Tian Zhou, Ying** Wang, Huiqing Liu, Ruining Ma, **ke Cheng and Yong Li incorrec...
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Article
Open AccessTRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain
Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1...
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Article
Open AccessSelective potentiation of 2-APB-induced activation of TRPV1–3 channels by acid
Temperature-sensitive TRP channels are important for responses to pain and inflammation, to both of which tissue acidosis is a major contributing factor. However, except for TRPV1, acid-sensing by other Thermo...
