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  1. Article

    Open Access

    CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements

    Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides (ASOs). However, determining promising targets is hampe...

    Yocelyn Recinos, Dmytro Ustianenko, Yow-Tyng Yeh, **aojian Wang… in Nature Communications (2024)

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  2. No Access

    Article

    Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling

    Hypoxia and increased levels of inflammatory cytokines in the joints are characteristics of rheumatoid arthritis (RA). However, the effects of hypoxia and tumor necrosis factor-α (TNF-α) on interleukin (IL)-6 ...

    Guofen Wang, Junsong Wang, **an Li, Qiyang Wu, Ruifeng Yao, **n**g Luo in Inflammation (2023)

  3. Article

    Open Access

    On the force field optimisation of \(\beta\) -lactam cores using the force field Toolkit

    When employing molecular dynamics (MD) simulations for computer-aided drug design, the quality of the used force fields is highly important. Here we present reparametrisations of the force fields for the core ...

    Qiyang Wu, Tianyang Huang, Songyan **a… in Journal of Computer-Aided Molecular Design (2022)

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  4. Article

    Open Access

    A paper-based microfluidic platform with shape-memory-polymer-actuated fluid valves for automated multi-step immunoassays

    Smart fluid manipulation with automatically controlled paper valves will enable automated and multi-step immunoassays on paper-based microfluidic devices. In this work, we present an integrated paper-based mic...

    Hao Fu, Pengfei Song, Qiyang Wu, Chen Zhao, Peng Pan… in Microsystems & Nanoengineering (2019)

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  5. No Access

    Chapter and Conference Paper

    A Comprehensive Analytical Model and Experimental Validation of Z-shaped Electrothermal Microactuators

    This paper presents a comprehensive analytical model for a Z-shaped electrothermal microactuator operating in air condition. The model provides the estimate of the tip displacement of the microactuator directl...

    Zhuo Zhang, Weize Zhang, Qiyang Wu… in Recent Advances in Mechanism Design for Ro… (2015)

  6. No Access

    Article

    Structure and bio-properties of extracellular polysaccharide from Bacillus sp. strain LBP32 Isolated from LUOBOPO desert

    A gray and low viscosity extracellular polysaccharide (EPS) composed of N-acetylglucosamine, xylose, and mannose was isolated from culture medium of Bacillus sp. strain LBP32 by ethanol precipitation followed by ...

    Honggui Wan, Jianfeng Yuan, **anyang Shan… in Biotechnology and Bioprocess Engineering (2011)