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Article
Differential Effects of Increasing Vapor Pressure Deficit on Photosynthesis at Steady State and Fluctuating Light
Increasing photosynthetic efficiency in fluctuating light is an important strategy to improve plant growth. In nature, fluctuating light often occurs concomitantly with the change in vapor pressure deficit (VP...
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Article
Rockburst Intensity Grade Prediction Based on Data Preprocessing Techniques and Multi-model Ensemble Learning Algorithms
Rockburst is a mine dynamic disaster caused by the rapid release of elastic strain energy of surrounding rock. As the depth of engineering project operations increases, accurate classification of rockburst int...
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Article
Simple Circuit Implementation of String Scaling Fractional-order Memristor with Fixed Valid Frequency Range
Scaling fractional-order memristors (fracmemristors) are a new research topic. Although remarkable progress has been made in the study of such memristors, there are some problems that require further study, fo...
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Article
Open AccessMelatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage pol...
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Article
Open AccessSingle-cell insights: pioneering an integrated atlas of chromatin accessibility and transcriptomic landscapes in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) poses a growing health threat, elevating heart failure risk in diabetic individuals. Understanding DCM is crucial, with fibroblasts and endothelial cells playing pivotal roles in ...
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Article
Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm
To establish the dynamic treatment strategy of Chinese medicine (CM) for metastatic colorectal cancer (mCRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment str...
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Article
Integrating single-cell and bulk RNA sequencing reveals CK19 + cancer stem cells and their specific SPP1 + tumor-associated macrophage niche in HBV-related hepatocellular carcinoma
Cytokeratin 19-positive cancer stem cells (CK19 + CSCs) and their tumor-associated macrophages (TAMs) have not been fully explored yet in the hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
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Article
Open AccessRecent trends in preparation and biomedical applications of iron oxide nanoparticles
The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable and...
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Article
Open AccessSingle-nucleus transcriptome sequencing reveals hepatic cell atlas in pigs
As the largest substantive organ of animals, the liver plays an essential role in the physiological processes of digestive metabolism and immune defense. However, the cellular composition of the pig liver rema...
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Article
Comparison of vonoprazan-based with rabeprazole-based dual therapy for treatment-naive patients of Helicobacter pylori infection: a prospective, multi-center, randomized controlled study
The application of vonoprazan significantly improved the eradication rate of Helicobacter pylori (H. pylori). This study aimed to compare efficacy and safety of the 10-day vonoprazan–amoxicillin (VA) and 14-day r...
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Article
Open AccessAdvanced application of nanotechnology in active constituents of Traditional Chinese Medicines
Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their...
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Article
Open AccessRadiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Bi...
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Article
Head and neck MRI-based T stage and [18F]FDG PET/CT-based N/M stage improved prognostic stratification in primary nasopharyngeal carcinoma
To evaluate whether MRI-based T stage (TMRI), [18F]FDG PET/CT-based N (NPET/CT), and M stage (MPET/CT) are superior in NPC patients’ prognostic stratification based on long-term survival evidences, and whether TN...
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Article
Open AccessPotential regulatory role of the Nrf2/HMGB1/TLR4/NF-κB signaling pathway in lupus nephritis
Systemic lupus erythematosus is an autoimmune disease that involves multiple organ systems. One of its major complications, lupus nephritis (LN), is associated with a high mortality rate, and children-onset LN...
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Article
Open Accessα1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation
Embryo implantation into the uterus is the gateway for successful pregnancy. Proper migration and invasion of embryonic trophoblast cells are the key for embryo implantation, and dysfunction causes pregnancy f...
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Article
Global dynamics of a tuberculosis model with age-dependent latency and time delays in treatment
Since there exists heterogeneity in incubation periods of tuberculosis and a time lag between treatment and recovery. In this study, we develop a tuberculosis model that takes into account age-dependent latenc...
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Article
Secondary Metabolites of Medicago sativa Infected with Leptosphaerulina australis and Antifungal Activity
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Article
Open AccessCamrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial
Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for refractory recurrent/metastatic nasopharyngeal carcinom...
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Article
Electroacupuncture in Treatment of Acute Gastrointestinal Injury in Patients with Severe Traumatic Brain Injury: A Multicenter Randomized Controlled Trial
To evaluate whether electroacupuncture (EA) would improve gastrointestinal function and clinical prognosis in patients with severe traumatic brain injury (TBI) complicocted by acute gastrointestinal injury (AGI).
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Article
Han family with essential tremor caused by the P421L variant of the TENM4 gene in China
Essential tremor (ET) is an autosomal dominant inheritance disorder. Mutations in fusion sarcoma (FUS), mitochondrial serine peptidase 2 (HTRA2), teneurin transmembrane protein 4 (TENM4), sortilin1 (SORT1), SCN11...
