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Article
Perioperative complications of middle cerebral artery occlusion in rats alleviated by human umbilical cord mesenchymal stem cells
For acute ischemic stroke treatment, the limitations of treatment methods and the high incidence of perioperative complications seriously affect the survival rate and postoperative recovery of patients. Human ...
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Article
Open AccessIntegrated transcriptome and metabolome analysis reveals the molecular responses of Pardosa pseudoannulata to hypoxic environments
Terrestrial organisms are likely to face hypoxic stress during natural disasters such as floods or landslides, which can lead to inevitable hypoxic conditions for those commonly residing within soil. Pardosa pseu...
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Article
Open AccessCombination of MRI-based prediction and CRISPR/Cas12a-based detection for IDH genoty** in glioma
Early identification of IDH mutation status is of great significance in clinical therapeutic decision-making in the treatment of glioma. We demonstrate a technological solution to improve the accuracy and reli...
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Article
Open AccessA cocktail nanovaccine targeting key entry glycoproteins elicits high neutralizing antibody levels against EBV infection
Epstein-Barr virus (EBV) infects more than 95% of adults worldwide and is closely associated with various malignancies. Considering the complex life cycle of EBV, develo** vaccines targeting key entry glycop...
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Article
Open AccessCharacterization of the intestinal microbiota in MSM with HIV infection
HIV-infected persons demonstrate notable disturbances in their intestinal microbiota; however, the impact of intestinal microbiota on HIV susceptibility in men who have sex with men (MSM), as well as the effec...
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Article
Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy
We previously demonstrated that ginsenoside Re (G-Re) has protective effects on acute kidney injury. However, the underlying mechanism is still unclear. In this study, we conducted a meta-analysis and pathway ...
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Article
ZnO Nanoparticles and Soil Fauna Affect Nutrient Transfer via Effects on Soil Fungal Community During Returned Wheat Straw Decomposition
The decomposition of returned straw is increasing facing the negative impacts by metal nanoparticles (NPs), however, which may be modulated by soil fauna and this modulation effect is unclear. Here, the intera...
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Article
Open AccessIntegrated optimization modelling framework for low-carbon and green regional transitions through resource-based industrial symbiosis
The development and utilization of bulk resources provide the basic material needs for industrial systems. However, most current resource utilization patterns are unsustainable, with low efficiencies and high ...
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Article
Study of radiochemotherapy decision-making for young high-risk low-grade glioma patients using a macroscopic and microscopic combined radiomics model
As a few types of glioma, young high-risk low-grade gliomas (HRLGGs) have higher requirements for postoperative quality of life. Although adjuvant chemotherapy with delayed radiotherapy is the first treatment ...
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Article
Open AccessMas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there is no effective treatment strategy to alleviate outcomes of these p...
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Article
Open AccessTriple oxygen isotope compositions reveal transitions in the moisture source of West China Autumn Precipitation
The isotopic composition has long been used to investigate the factors influencing precipitation, whereas the variations of event-based precipitation isotopes caused by moisture transition and synoptic meteoro...
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Article
Preparation and Synergistic Antibacterial Effect of Zinc and Cerium Co-Doped Silica
In this study, a SiO2 support was modified with zinc and cerium to obtain a material with excellent antibacterial properties. The optimal preparation conditions resulting in the highest antibacterial efficiency (...
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Article
PAX2 mediated upregulation of ESPL1 contributes to cisplatin resistance in bladder cancer through activating the JAK2/STAT3 pathway
Extra spindle-polar body like 1 (ESPL1) is associated with the development of a variety of cancers, including bladder cancer, and is closely related to chemoresistance. In this study, we aimed to reveal the ro...
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Article
A profile analysis of problematic smartphone usage among college students during coronavirus disease 2019: Relations with the impact of news reports
The coronavirus disease 2019 (COVID-19) outbreak was the first pandemic to occur in a fully globalized society. The aims of the study were to explore the state of problematic smartphone use (PSU) and its risk ...
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Article
Effect of Molecular Weight on Thermoelectric Performance of P3HT Analogues with 2-Propoxyethyl Side Chains
By replacing hexyl chains in poly(3-hexylthiophene) (P3HT) with 2-propoxyethyls, four poly(3-(2-propoxyethyl)thiophene) (P3POET) homopolymers with comparable polydispersity indexes (PDI) and regioregularities ...
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Article
lncCPSET1 acts as a scaffold for MLL2/COMPASS to regulate Bmp4 and promote the formation of chicken primordial germ cells
Primordial germ cells (PGCs) are the ancestors of female and male germ cells. Recent studies have shown that long non-coding RNA (lncRNA) and histone methylation are key epigenetic factors affecting PGC format...
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Article
Open AccessEncoding ordered structural complexity to covalent organic frameworks
Installing different chemical entities onto crystalline frameworks with well-defined spatial distributions represents a viable approach to achieve ordered and complex synthetic materials. Herein, a covalent or...
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Article
Evaluation of changes in college students’ experience of family harmony before, during, and after the COVID-19 pandemic
Family harmony is a state of good relations among family members, smooth communication, mutual support and reasonable conflict resolution. Maintaining good family harmony is important for improving individual ...
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Article
Open AccessTrans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma
Almost all Glioblastoma (GBM) are either intrinsically resistant to the chemotherapeutical drug temozolomide (TMZ) or acquire therapy-induced mutations that cause chemoresistance and recurrence. The genome mai...
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Article
Open AccessMore Efficient Approach: Independent Diagnostic Value of Audiovisual Sexual Stimulation for Psychogenic Erectile Dysfunction
The diagnostic value of audiovisual sexual stimulation (AVSS) for psychogenic erectile dysfunction (ED) is still unclear. We investigated the independent diagnostic value and optimal cut-off parameter of AVSS ...
