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    Engineering miniature IscB nickase for robust base editing with broad targeting range

    IscB has a similar domain organization to Cas9, but the small size of IscB is better suited for delivery by adeno-associated virus. To improve the low editing efficiency of OgeuIscB (IscB from human gut metage...

    Linxiao Han, Yueer Hu, Qiqin Mo, Hao Yang, Feng Gu, Fang Bai in Nature Chemical Biology (2024)