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Article
Open AccessOsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate
The chromatin modifier GRAIN WEIGHT 6a (GW6a) enhances rice grain size and yield. However, little is known about its gene network determining grain size. Here, we report that MITOGEN-ACTIVED PROTEIN KINASE 6 (...
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Article
Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124
miR-124 is a miRNA predominantly expressed in the nervous system and accounts for more than a quarter of the total miRNAs in the brain. It regulates neurogenesis, neuronal differentiation, neuronal maturation,...
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Altitudinal Pattern of Soil Organic Carbon and Nutrients in a Tropical Forest in Puerto Rico
Tropical forests have the highest net primary productivity and soil carbon flux yet bear large uncertainties in being a carbon sink or source under changes in climate. To better understand the responses of tro...
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Article
Prolonged coastal inundation detected with synthetic aperture radar significantly retarded functional recovery of mangroves after major hurricanes
Hurricanes are major threats to coastal mangrove ecosystems. Inundation has been implicitly reported to associate with mangrove damages and mortality. However, there have been no spatial statistical analyses o...
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Article
Overexpression of microRNA-100-5p attenuates the endothelial cell dysfunction by targeting HIPK2 under hypoxia and reoxygenation treatment
MicroRNAs (miRNAs) are important regulators of many cellular processes, and the dysregulation of miRNAs is associated with various diseases. MiR-100-5p is revealed to be downregulated in gestational hypertensi...
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Article
LncRNA SNHG16 regulates trophoblast functions by the miR-218-5p/LASP1 axis
Altered placental development and function lead to placental diseases such as preeclampsia (PE) which is mainly characterized by insufficient trophoblast invasion and abnormally invasive placenta disorders. Lo...
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Article
Fast crystal growth at ultra-low temperatures
It is believed that the slow liquid diffusion and geometric frustration brought by a rapid, deep quench inhibit fast crystallization and promote vitrification. Here we report fast crystal growth in charged col...
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Article
Open AccessImpairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis
Profiling studies have revealed considerable phenotypic heterogeneity in cancer-associated fibroblasts (CAFs) present within the tumour microenvironment, however, functional characterisation of different CAF s...
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Article
High-Efficiency Diode-Resonantly-Pumped Tm:Lu2O3 Ceramic Laser with Near Diffraction-Limited Beam Quality
We demonstrate an efficient diode-pumped Tm:Lu2O3 ceramic laser with resonant pum** scheme. A laser diode at 1.7 μm is employed as the pump source. With an absorbed pump power of 8.2 W, the diode-pumped Tm:Lu2O
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Article
Open AccessTumour kinome re-wiring governs resistance to palbociclib in oestrogen receptor positive breast cancers, highlighting new therapeutic modalities
Combination of CDK4/6 inhibitors and endocrine therapy improves clinical outcome in advanced oestrogen receptor (ER)-positive breast cancer, however relapse is inevitable. Here, we show in model systems that o...
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Article
Open AccessCasparian strip membrane domain proteins in Gossypium arboreum: genome-wide identification and negative regulation of lateral root growth
Root systems are critical for plant growth and development. The Casparian strip in root systems is involved in stress resistance and maintaining homeostasis. Casparian strip membrane domain proteins (CASPs) ar...
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Article
Transcriptome-wide identification and profiling of miRNAs in a stress-tolerant conifer Sabina chinensis
miRNAs are important regulatory components involving in many biological processes, including plant development, vegetative and reproductive growth, and stress response. However, identification and characteriza...
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Article
Open AccessCorrection to: Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer
After publication of the original article [1], we were notified that an author’s surname has been erroneously spelled. Elisabetta Maragoni’s family name should be replaced with Marangoni.
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Article
Open AccessImpact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients
Endocrine therapy reduces breast cancer mortality by 40%, but resistance remains a major clinical problem. In this study, we sought to investigate the impact of aromatase inhibitor (AI) therapy on gene express...
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Article
Open AccessCombination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer
Endocrine therapies are still the main strategy for the treatment of oestrogen receptor-positive (ER+) breast cancers (BC), but resistance remains problematic. Cross-talk between ER and PI3K/AKT/mTORC has been...
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Article
Landscape-Level Consequences of Rising Sea-Level on Coastal Wetlands: Saltwater Intrusion Drives Displacement and Mortality in the Twenty-First Century
Coastal wetlands are shrinking rapidly due to land-use activities. Accelerated sea-level rise (SLR) associated to the warming climate is also affecting coastal wetlands, particularly in islands with limited co...
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Article
Open AccessMenstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer
The major changes in hormone levels that occur through the menstrual cycle have been postulated to affect the expression of hormone-regulated and proliferation-associated genes (PAGs) in premenopausal ER+ brea...
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Article
Phosphate-solubilizing bacteria will not significantly remobilize soil cadmium remediated by weathered coal
Cadmium (Cd) re-mobilize by phosphate-solubilizing bacteria (PSB) from immobilization contaminated soil has drawn great attention due to its serious threat to human health through food chain. However, Cd bindi...
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Article
Open AccessMetabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation
The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic v...
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Article
Open AccessIn-depth transcriptome characterization uncovers distinct gene family expansions for Cupressus gigantea important to this long-lived species’ adaptability to environmental cues
Cupressus gigantea, a rare and endangered tree species with remarkable medicinal value, is endemic to the Tibetan Plateau. Yet, little is known about the underlying genetics of the unique ecological adaptability ...
