-
Article
Prenatal Exposure to Neonicotinoids and the Associations with Neonatal Birth Outcomes and Maternal Health in South China
Neonicotinoids (NEOs) are a class of novel insecticides which are used for pest control and crop protection all over the world. However, there is only scarce research concerning whether NEO exposure adversely ...
-
Article
Altered functional-structural coupling may predict Parkinson’s patient’s depression
We aimed to elucidate the neurobiological basis of depression in Parkinson’s disease and identify potential imaging markers for depression in patients with Parkinson’s disease. We recruited 43 normal controls ...
-
Article
Transport mechanism of presynaptic high-affinity choline uptake by CHT1
Choline is a vital nutrient and a precursor for the biosynthesis of essential metabolites, including acetylcholine (ACh), that play a central role in fetal development, especially in the brain. In cholinergic ...
-
Article
Open AccessStructural bases of inhibitory mechanism of CaV1.2 channel inhibitors
The voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain an...
-
Article
Open AccessYAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression
Hippo-Yes-associated protein 1 (YAP1) plays an important role in gastric cancer (GC) progression; however, its regulatory network remains unclear. In this study, we identified Copine III (CPNE3) was identified as...
-
Article
Open AccessAsialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptid...
-
Article
Open AccessNew insights into the correlations between circulating tumor cells and target organ metastasis
Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic f...
-
Article
Open AccessOn-demand light-driven release of droplets stabilized via a photoresponsive fluorosurfactant
Water-in-oil droplets have emerged as promising microreactors for high-throughput biochemical analysis due to their features of reduced sample consumption and automated operation. For a typical screening appli...
-
Article
A nationwide investigation of trace elements in rice and wheat flour in China: Levels, spatial distributions and implications for human exposure
Rises in trace element contents in rice and wheat flour, which are staple foods for almost all the Chinese population, associated with rapid economic development have raised major concerns. This study aimed to...
-
Article
In-situ electrochemical restructuring of Cu2BiSx solid solution into Bi/CuxSy heterointerfaces enabling stabilization intermediates for high-performance CO2 electroreduction to formate
Bismuth-based materials are prevalent catalysts for CO2 electroreduction to formate, enduring high hydrogen evolution reactions and inadequate activity and stability. Herein, we reveal that in-situ electrochemica...
-
Article
Open AccessStabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding
There is great interest to engineer in vitro models that allow the study of complex biological processes of the microvasculature with high spatiotemporal resolution. Microfluidic systems are currently used to eng...
-
Article
Open AccessUnleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targ...
-
Article
Open AccessDissecting the microbial community structure of internal organs during the early postmortem period in a murine corpse model
Microorganisms distribute and proliferate both inside and outside the body, which are the main mediators of decomposition after death. However, limited information is available on the postmortem microbiota cha...
-
Article
Construction of hollow mesoporous ZnMn2O4/C microspheres with carbon nanotubes embedded in shells for high-performance aqueous zinc ions batteries
Recently, rechargeable zinc-ion batteries have been considered as the future development direction of large-scale energy storage due to their low price, safety, environmental friendliness, and excellent electr...
-
Chapter and Conference Paper
Efficiently Approximating High-Dimensional Pareto Frontiers for Tree-Structured Networks Using Expansion and Compression
Real-world decision-making often involves working with many distinct objectives. However, as we consider a larger number of objectives, performance degrades rapidly and many instances become intractable. Our g...
-
Article
Association between fetal exposure to polycyclic aromatic hydrocarbons and low birth weight: a case–control study in Shenzhen, China
The potential hazards of polycyclic aromatic hydrocarbons (PAHs) on fetus development have raised widespread concerns in recent years, although current epidemiological findings are conflicting. The aim of this...
-
Article
Measuring the system resilience of project portfolio network considering risk propagation
The paper presents the model resilience measurement based on the complex network theory and analyzes the resilience of project portfolio network considering risk propagation. The model can be used to evaluate ...
-
Article
Open AccessFunctionalized graphene grids with various charges for single-particle cryo-EM
A major hurdle for single particle cryo-EM in structural determination lies in the specimen preparation impaired by the air-water interface (AWI) and preferential particle-orientation problems. In this work, w...
-
Article
Analysis of Postmortem Intestinal Microbiota Successional Patterns with Application in Postmortem Interval Estimation
Microorganisms play a vital role in the decomposition of vertebrate remains in natural nutrient cycling, and the postmortem microbial succession patterns during decomposition remain unclear. The present study ...
-
Article
Endothelial Protection of Vasoactive Intestinal Peptide Enhances Angiogenesis Mediated by eNOS Pathway Following Focal Cerebral Ischemia in Rats
In the present study, we investigated the effects of vasoactive intestinal peptide (VIP) on angiogenesis after cerebral ischemia and the mechanism underlying such effects. After a 2 h middle cerebral artery oc...
