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  1. Article

    Open Access

    Hydrogen peroxide-activatable antioxidant prodrug as a targeted therapeutic agent for ischemia-reperfusion injury

    Overproduction of hydrogen peroxide (H2O2) causes oxidative stress and is the main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury. Suppression of oxidative stress is therefore critical in the tr...

    Dongwon Lee, Seunggyu Park, Soochan Bae, Dahee Jeong, Minhyung Park… in Scientific Reports (2015)

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  2. Article

    Open Access

    H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents

    The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form of ROS produced during I/R, cause...

    Dongwon Lee, Soochan Bae, Donghyun Hong, Hyungsuk Lim, Joo Heung Yoon… in Scientific Reports (2013)

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  3. No Access

    Article

    Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion

    Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during...

    Sangita Choudhury, Soochan Bae, Qingen Ke, Ji Yoo Lee… in Basic Research in Cardiology (2011)

  4. No Access

    Article

    Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditis

    The present study was designed to determine whether cardiac inflammation is important for the successful homing of stem cells to the heart after intravenous injection in a murine myocarditis model. Male Bagg a...

    Sohail Malek, Emel Kaplan, Ju-Feng Wang, Qingen Ke, Jamal S. Rana… in Pflügers Archiv (2006)