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Article
Open AccessExtracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expressio...
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Article
Open AccessA qPCR method for genome editing efficiency determination and single-cell clone screening in human cells
CRISPR/Cas9 technology has been widely used for targeted genome modification both in vivo and in vitro. However, an effective method for evaluating genome editing efficiency and screening single-cell clones for d...
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Article
Open AccessApigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner
Apigenin (APG) is an edible plant-derived flavonoid that shows modest antitumor activities in vitro and in vivo. APG treatment results in cell growth arrest and apoptosis in various types of tumors by modulating ...
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Article
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding
Gong-Hong Wei, Jussi Taipale and colleagues show that a prostate cancer risk allele at 6q22 enhances HOXB13 chromatin binding at this locus, leading to increased allele-specific expression of RFX6. They further s...
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Article
Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK
Galangin, an active flavonoid present at high concentration in Alpinia officinarum Hance and propolis, shows cytotoxicity towards several cancer cell lines, including melanoma. However, the specific cellular t...
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Article
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions
Many cancer cell types are resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Here, we examined whether HSP70 suppression by small interfering RNA (siRNA) sensitize...
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Article
Oridonin: A promising anticancer drug from China
Oridonin, a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, has been proved to possess remarkable anticancer activity, in addition to its potential in antiinflammation and antibacteria. The purpose of...
