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    Article

    MET exon 14 skip** mutation drives cancer progression and recurrence via activation of SMAD2 signalling

    c-Met encoded by the proto-oncogene MET, also known as hepatocyte growth factor (HGF) receptor, plays a crucial role in cellular processes. MET exon 14 skip** alteration (METΔ14EX) is a newly discovered MET ...

    Qiaoyan Liang, Yajun Hu, Qingyun Yuan, Min Yu, Huijie Wang in British Journal of Cancer (2024)

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    Article

    Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors

    Purpose Programmed cell death 1 (PD-1), which is upregulated under the continuous induction of the tumor microenvironment, causes chimeric antigen receptor (CAR)-T cell hypofunction via interaction with programme...

    **ngxing Yuan, Zujun Sun, Qingyun Yuan, Weihua Hou in Investigational New Drugs (2021)