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Article
Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4–12 years: a real-world study
To determine the efficacy and safety of perampanel (PER) as an adjunctive therapy in children aged 4–12 years with epilepsy.
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Article
Open AccessDeciphering antifungal and antibiofilm mechanisms of isobavachalcone against Cryptococcus neoformans through RNA-seq and functional analyses
Cryptococcus neoformans has been designated as critical fungal pathogens by the World Health Organization, mainly due to limited treatment options and the prevalence of antifungal resistance. Consequently, the ut...
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Chapter and Conference Paper
Application of Artificial Intelligence Algorithms in Mathematical Modeling Optimization Research
Mathematics plays an increasingly important role in students’ learning and life, especially in mathematical modeling competitions, which have become an important indicator for evaluating students’ extracurricu...
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Chapter and Conference Paper
Research on the Recommendation Method of Postgraduate Supervisor Based on Natural Intelligence Information Integration
In response to the difficulty of choosing a supervisor for prospective postgraduate, this research proposes a method for recommending postgraduate supervisors. The method starts with prospective postgraduate d...
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Article
Open AccessA longer wood growing season does not lead to higher carbon sequestration
A reliable assessment of forest carbon sequestration depends on our understanding of wood ecophysiology. Within a forest, trees exhibit different timings and rates of growth during wood formation. However, the...
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Article
Open AccessGlutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment
Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration. To da...
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Article
Majority of transferred mosaic embryos developed healthy live births revealed by a preclinical study using embryonic morphology assessment and noninvasive PGT-A on cell-free DNA in blastocoel fluid
This preclinical study aimed to evaluate whether using transferred mosaic embryos (primarily selected by embryonic morphology assessment (EMA) and compared by the noninvasive preimplantation genetic testing fo...
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Article
Electrochemical corrosion and protection of low-temperature sintered silver nanoparticle paste in NH4Cl solution
Corrosion behavior of low-temperature sintered silver nanoparticle (AgNP) paste in NH4Cl solution was investigated using electrochemical measurements (electrochemical impedance, potentiodynamic polarization, and ...
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Article
Mechanisms of Action of Luteolin Against Single- and Dual-Species of Escherichia coli and Enterobacter cloacae and Its Antibiofilm Activities
Escherichia coli and Enterobacter cloacae are major foodborne pathogens and can form challenging single/mixed biofilms. A recent study demonstrated that luteolin (LUT) exhibits antibacterial activities against so...
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Article
Open AccessAnalysis of clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia that is spontaneously relieved
This study aimed to analyze the clinical and genetic characteristics of Chinese children with congenital hyperinsulinemia (CHI) that is spontaneously relieved.
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Article
Open AccessCellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the contraction of the heart in mammals. Though discovered over a century ago, the molecular and cellular features of the...
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Article
In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids
Unlike most organs that mature during the fetal period, the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis. Robust modelling of human testicular organogenesi...
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Article
An explicit-solvent hybrid QM and MM approach for predicting pKa of small molecules in SAMPL6 challenge
In this work we have developed a hybrid QM and MM approach to predict pKa of small drug-like molecules in explicit solvent. The gas phase free energy of deprotonation is calculated using the M06-2X density fun...
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Article
Absolute and relative pKa predictions via a DFT approach applied to the SAMPL6 blind challenge
In this work, quantum mechanical methods were used to predict the microscopic and macroscopic pKa values for a set of 24 molecules as a part of the SAMPL6 blind challenge. The SMD solvation model was employed wit...
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Article
A conventional chemical reaction for use in an unconventional assay: A colorimetric immunoassay for aflatoxin B1 by using enzyme-responsive just-in-time generation of a MnO2 based nanocatalyst
The authors describe a colorimetric immunoassay for the model nalyte aflatoxin B1 (AFB1). It is based on the just-in-time generation of an MnO2 nanocatalyst. Unlike previously developed immunoassay, the chromogen...
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Article
Comparing meteorological records between mountainous and valley bottom sites in the upper reaches of the Heihe River, northwestern China: implications for dendroclimatology
Tree-ring records from remote upland areas are widely used in climate reconstructions, but they are typically calibrated by meteorological data from low-lying areas. With the aim of assessing relationships bet...
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Article
Open AccessCXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer
The activation of CXCL12/CXCR4 axis is associated with potential progression of cancer, such as invasion, metastasis and chemoresistance. However, the underlying mechanisms of CXCL12/CXCR4 axis and cancer prog...
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Article
Electrochemical co-deposition of reduced graphene oxide-gold nanocomposite on an ITO substrate and its application in the detection of dopamine
The simultaneous deposition of rGO and gold nanostructures has been achieved by electrodeposition from mixed solutions containing graphene oxide (GO) and a gold precursor. Scanning electron microscope (SEM), R...
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Article
Open AccessIntegrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation
Fragile X syndrome (FXS) patients carry the expansion of over 200 CGG repeats at the promoter of fragile X mental retardation 1 (FMR1), leading to decreased or absent expression of its encoded fragile X mental re...
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Article
Analytical derivative techniques for TDDFT excited-state properties: Theory and application
We review our recent work on the methodology development of the excited-state properties for the molecules in vacuum and liquid solution. The general algorithms of analytical energy derivatives for the specifi...
