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  1. Article

    Open Access

    HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia

    Acute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A fundamental problem in treating AML is that conventional therapy fails to eliminate LSCs, which can reinitiate leukemia...

    Qianze Dong, Yan **u, Yang Wang, Christina Hodgson… in Nature Communications (2022)

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  2. No Access

    Article

    Lipopolysaccharide stimulates endogenous β-glucuronidase via PKC/NF-κB/c-myc signaling cascade: a possible factor in hepatolithiasis formation

    Hepatolithiasis is commonly encountered in Southeastern and Eastern Asian countries, but the pathogenesis mechanism of stone formation is still not well understood. Now, the role of endogenous β-glucuronidase ...

    Dianbo Yao, Qianze Dong, Yu Tian, Chaoliu Dai… in Molecular and Cellular Biochemistry (2018)

  3. No Access

    Article

    Overexpression of CASS4 promotes invasion in non-small cell lung cancer by activating the AKT signaling pathway and inhibiting E-cadherin expression

    The role of Crk-associated substrate (CAS) family members in regulating invasion and metastasis has been described in several cancers. As the fourth member of the CAS family, CASS4 is also related with positiv...

    Ailin Li, Weiwei Zhang, Huifang **a, Yuan Miao, Hai**g Zhou… in Tumor Biology (2016)

  4. No Access

    Article

    Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1

    Rab23 overexpression has been implicated in several human cancers. However, its biological roles and molecular mechanism in astrocytoma have not been elucidated. The aim of this study is to explore clinical si...

    Minghao Wang, Qianze Dong, Yunjie Wang in Tumor Biology (2016)

  5. No Access

    Article

    RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion

    RASSF4 has been implicated as a tumor suppressor in several human cancers. Its clinical significance and biological characteristics in human nonsmall cell lung cancer (NSCLC) have not been explored yet. In thi...

    Yong Han, Qianze Dong, Jie Hao, Lin Fu, Xu Han, **aoying Zheng, Enhua Wang in Tumor Biology (2016)

  6. No Access

    Article

    CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer

    CRKL is an adapter protein which is overexpressed in many malignant tumors and plays crucial roles in tumor progression. However, expression pattern and biological roles of CRKL in pancreatic cancer have not b...

    Lin Fu, Qianze Dong, Chengyao **e, Yan Wang, Qingchang Li in Tumor Biology (2015)

  7. No Access

    Article

    Diversin is overexpressed in human gliomas and its depletion inhibits proliferation and invasion

    Previous study indicated diversin overexpression in human cancers. However, its expression pattern in human gliomas and the molecular mechanisms of diversin on cancer progression have not been characterized. I...

    Minghao Wang, **nmiao Yu, Qianze Dong, Yunjie Wang in Tumor Biology (2014)

  8. No Access

    Article

    Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis

    The purpose of this study is to identify a better potential biomarker for the prognosis of patients with non-small cell lung cancer (NSCLC). The expressions of Nek2, MCM7, and Ki-67 were evaluated in 270 NSCLC...

    **nwen Zhong, **aojiao Guan, Qianze Dong, Shize Yang, Wenke Liu, Lin Zhang in Tumor Biology (2014)

  9. No Access

    Article

    Rsf-1 overexpression correlates with poor prognosis and cell proliferation in colon cancer

    Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its biological roles in...

    Shuli Liu, Qianze Dong, Enhua Wang in Tumor Biology (2012)