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Article
Open AccessPervasive downstream RNA hairpins dynamically dictate start-codon selection
Translational reprogramming allows organisms to adapt to changing conditions. Upstream start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in regulating translation by providing al...
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Article
Open AccessOnline single-cell data integration through projecting heterogeneous datasets into a common cell-embedding space
Computational tools for integrative analyses of diverse single-cell experiments are facing formidable new challenges including dramatic increases in data scale, sample heterogeneity, and the need to informativ...
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Article
Open AccessSingle-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation
The combined use of transcriptome and translatome as indicators of gene expression profiles is usually more accurate than the use of transcriptomes alone, especially in cell types governed by translational reg...
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Article
Open AccessDifferential analysis of RNA structure probing experiments at nucleotide resolution: uncovering regulatory functions of RNA structure
RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcrip...
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Article
Open AccessRNA structure probing reveals the structural basis of Dicer binding and cleavage
It is known that an RNA’s structure determines its biological function, yet current RNA structure probing methods only capture partial structure information. The ability to measure intact (i.e., full length) R...
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Article
Open AccessSCALE method for single-cell ATAC-seq analysis via latent feature extraction
Single-cell ATAC-seq (scATAC-seq) profiles the chromatin accessibility landscape at single cell level, thus revealing cell-to-cell variability in gene regulation. However, the high dimensionality and sparsity ...
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Open AccessVisuospatial task-related prefrontal activity is correlated with negative symptoms in schizophrenia
Control of attention is thought to be specifically impaired in schizophrenia due to abnormal function in the prefrontal cortex (PFC). The PFC plays a critical role in the identification of relevant stimuli and...
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Open AccessHigh-quality mesoporous graphene particles as high-energy and fast-charging anodes for lithium-ion batteries
The application of graphene for electrochemical energy storage has received tremendous attention; however, challenges remain in synthesis and other aspects. Here we report the synthesis of high-quality, nitrog...
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Open AccessTranscriptional profiling provides new insights into the role of nitric oxide in enhancing Ganoderma oregonense resistance to heat stress
Ganoderma is well known for its use in traditional Chinese medicine and is widely cultivated in China, Korea, and Japan. Increased temperatures associated with global warming are negative...
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Open AccessOne-Step Synthesis of Microporous Carbon Monoliths Derived from Biomass with High Nitrogen Do** Content for Highly Selective CO2 Capture
The one-step synthesis method of nitrogen doped microporous carbon monoliths derived from biomass with high-efficiency is developed using a novel ammonia (NH3)-assisted activation process, where NH3 serves as bot...
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Open AccessInward lithium-ion breathing of hierarchically porous silicon anodes
Silicon has been identified as a highly promising anode for next-generation lithium-ion batteries (LIBs). The key challenge for Si anodes is large volume change during the lithiation/delithiation cycle that re...
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Erratum: Structural imprints in vivo decode RNA regulatory mechanisms
Nature 519, 486–490 (2015); doi: 10.1038/nature14263 In Fig. 2a of this Letter, an error in the placement of the labels on the pie chart was introduced during the production process. The correct numbers were r...
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Correction: Corrigendum: Structure-based prediction of protein–protein interactions on a genome-wide scale
Nature 490, 556–560 (2012); doi:10.1038/nature11503 In this Letter, one of the points shown in Fig. 2 and Supplementary Figs 8, 9 and Supplementary Table 4 reflects the presence of interactions that had been e...