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  1. Article

    Open Access

    Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET–mutant thyroid cancer

    Genetic alternation of REarranged during Transfection (RET) that leads to constitutive RET activation is a crucial etiological factor for thyroid cancer. RET is known to regulate mitochondrial processes, although...

    Wen**g Chen, Sophie Dream, Pui-Yin Leung, Pui-Kei Wu… in npj Precision Oncology (2024)

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  2. No Access

    Article

    Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability

    The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin depletion can selectively induce death of immortalized ...

    Pui-Kei Wu, Seung-Keun Hong, Dmytro Starenki, Kiyoko Oshima, Hao Shao… in Oncogene (2020)

  3. No Access

    Article

    Anticancer activities and the drug targets of botanical saponins from a medicinal herb, gynostemma pentaphyllum

    W. L. Wendy Hsiao, William Chi Shing Tai… in Journal of Acupuncture and Tuina Science (2008)