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Article
Open AccessGenome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy,...
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Article
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associa...
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Article
Genetic analyses identify widespread sex-differential participation bias
Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of participation bias is challenging since it...
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Article
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.
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Article
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure...
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Article
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation
Thomas Hoffmann, Neil Risch and colleagues use longitudinal electronic health records from almost 100,000 individuals to conduct genome-wide association studies for blood pressure measurements. They find new s...
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Article
Open AccessRare coding TTN variants are associated with electrocardiographic QT interval in the general population
We have shown previously that noncoding variants map** around a specific set of 170 genes encoding cardiomyocyte intercalated disc (ID) proteins are more enriched for associations with QT interval than obser...
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Article
Open AccessBiophysical and structural considerations for protein sequence evolution
Protein sequence evolution is constrained by the biophysics of folding and function, causing interdependence between interacting sites in the sequence. However, current site-independent models of sequence evol...
