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Article
Efficacy of long-term albumin therapy in the treatment of decompensated cirrhosis
Decompensated liver cirrhosis has a poor prognosis, with a median overall survival of two to four years, which is worse than for many oncological disorders. These patients are highly susceptible to infections ...
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Article
To evaluate the prevalence of spontaneous portosystemic shunts in decompensated cirrhosis patients and its prognostic significance
Spontaneous portosystemic shunts (SPSS) are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates, probably as a consequence of worsening portal hypertension, but without ac...
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Article
A study of association between regulatory polymorphism in the IL-10 gene promoter region and acute viral hepatitis, and acute liver failure
The level of inflammatory cytokine Interleukin (IL)-10 is increased in patients infected with hepatitis-related acute liver failure (ALF), and this was thought to be because of the regulatory polymorphism in t...
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Article
Novel molecular alterations in the ORF 2 capsid gene of hepatitis E virus in patients with acute liver failure in North India
Hepatitis E virus (HEV) is evolving as a major global threat to public health, including in developed countries. We partially sequenced the ORF 2 capsid protein genes of HEV genomes from patients with acute li...
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Article
New insights into hepatitis C virus infection in the tribal-dominant part of Northeast India
Northeast India is known for the demographic heterogeneity of its tribal population, but there is no information about hepatitis C virus infection and associated risk factors. Anti-HCV was measured, HCV-RNA wa...
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Article
Open AccessImmunological and molecular epidemiological characteristics of acute and fulminant viral hepatitis A
Hepatitis A virus is an infection of liver; it is hyperendemic in vast areas of the world including India. In most cases it causes an acute self limited illness but rarely fulminant. There is growing concern a...
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Article
Surveillance of hepatitis E virus in sewage and drinking water in a resettlement colony of Delhi: what has been the experience?
Hepatitis E virus infection is one of the major causes of hepatitis and has been responsible for many sporadic waterborne hepatitis epidemics. We studied 141 cases of viral hepatitis in the Gokulpuri area and ...
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Article
Association of Tumor Necrosis Factor-Alpha Gene Promoter Polymorphisms with Acute Viral Hepatitis in the Indian Population
The key elements that determine the host response to either the self-limited or a severe fulminant form of liver disease are unclear. We have investigated the potential association of single nucleotide polymor...
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Article
Multifocal Epitheloid Hemangioendothelioma of Liver after Long-Term Oral Contraceptive Use—A Case Report and Discussion of Management Difficulties Encountered
A 43-year-old woman presented with right upper abdominal pain, on and off for 3–4 years. One year prior to her presentation, a space-occupying lesion was found in the right lobe of the liver, which was suspect...
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Article
Cytokine Levels of TGF-β, IL-10, and sTNFαRII in Type C Chronic Liver Disease
Cytokines play a key role in regulation of immunity and inflammation. The aim of the study was to detect serum levels of TGF-β, IL-10, and sTNFαRII in patients with type C chronic liver disease (CLD) and to co...
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Article
Response of Combination Therapy on Viral Load and Disease Severity in Chronic Hepatitis C
Influence of genotypes on viral kinetics and disease severity in chronic hepatitis C (CH-C) patients has been implicated, but requires further investigation. The 41 HCV patients were genotyped by restriction f...
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Article
Does Mutation of Hepatitis A Virus Exist in North India?
Human hepatitis A, a widespread infectious disease that is hyperendemic in vast areas of the world, results in the infection of the liver. Different human HAV strains of diverse geographic origin are remarkabl...
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Article
Prevalence of Hepatitis B Virus Genotype D in Precore Mutants Among Chronic Liver Disease Patients from New Delhi, India
Hepatitis B is one of the most important causes of chronic viral hepatitis world wide. Mutations in the precore region of the hepatitis B virus (HBV) genome are frequently found in hepatitis B envelope antigen...
