5 Result(s)
within
Prashant V. Shinde
English
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Article
Open AccessSlow viral propagation during initial phase of infection leads to viral persistence in mice
Immune evasion of pathogens can modify the course of infection and impact viral persistence and pathology. Here, using different strains of the lymphocytic choriomeningitis virus (LCMV) model system, we show t...
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Article
Publisher Correction: Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection
Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in resp...
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Article
Open AccessTNFα induced up-regulation of Na+,K+,2Cl− cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity
The devastating consequences of hepatic failure include hepatic encephalopathy, a severe, life threatening impairment of neuronal function. Hepatic encephalopathy is caused by impaired hepatic clearance of NH4 ...
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Article
Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection
Functional T cell exhaustion occurs during chronic viral infection or in tumor settings. Beyer et al. report that chronic inflammation mediated by the cytokine TNF is responsible for this dysfunction and that blo...
