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Chapter
Type-Specific Concordance in Young Diabetic Monozygotic Twins
In 1972, Tattersall and Pyke (1) indicated that the level of concordance for diabetes among monozygotic twins depended upon the age of onset of diabetes in the index twin. If diabetes developed before 40 years...
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Article
Downregulation of human FGF8 activity by antisense constructs in murine fibroblastic and human prostatic carcinoma cell systems
Previously, we described cloning of three alternatively spliced mRNA forms of human FGF8, a, b, and e, of which the b form is the major expressed species in both normal and tumor prostatic epithelial cells. In...
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Article
Mouse Prostate Cancer Cell Lines Established from Primary and Postcastration Recurrent Tumors
The clinical course of prostate cancer is grouped into two broad phases. The first phase, which is the growth of the androgen-dependent cancer (AD-Ca), responds well to androgen depletion treatment while the s...
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Article
Cancer Stem Cells and Microenvironment in Prostate Cancer Progression
For a study of interactions between the cancer-associated fibroblasts (CAFs) and the putative prostate cancer stem cells (CSCs), we used a conditional Pten deletion mouse model of prostatic adenocarcinoma to isol...
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Article
PI3K, Erk Signaling in BMP7-Induced Epithelial-Mesenchymal Transition (EMT) of PC-3 Prostate Cancer Cells in 2- and 3-Dimensional Cultures
We reported previously that bone morphogenetic protein 7 (BMP7) could induce epithelial-mesenchymal transition (EMT) in PC-3 prostate cancer cells grown in tissue culture plates. In this study, we examined BMP...