4 Result(s)

Article

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic instability may u...

Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie… in Nature Communications (2024)

Article

Publisher Correction: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia

Yingyue Zhou, Mari Tada, Zhangying Cai, Prabhakar S. Andhey… in Nature Immunology (2023)

Article

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression. Through integr...

Andrew L. Koenig, Irina Shchukina, Junedh Amrute… in Nature Cardiovascular Research (2022)

Article

Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, Amanda Swain… in Nature Medicine (2020)