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  1. No Access

    Article

    Defining cardiac functional recovery in end-stage heart failure at single-cell resolution

    Recovery of cardiac function is the holy grail of heart failure therapy yet is infrequently observed and remains poorly understood. In this study, we performed single-nucleus RNA sequencing from patients with ...

    Junedh M. Amrute, Lulu Lai, Pan Ma, Andrew L. Koenig… in Nature Cardiovascular Research (2023)

  2. Article

    Open Access

    Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

    Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression. Through integr...

    Andrew L. Koenig, Irina Shchukina, Junedh Amrute… in Nature Cardiovascular Research (2022)

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  3. Article

    Open Access

    Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle

    Cell fate decisions involved in vascular and hematopoietic embryonic development are still poorly understood. An ETS transcription factor Etv2 functions as an evolutionarily conserved master regulator of vascu...

    Brendan Chestnut, Satish Casie Chetty, Andrew L. Koenig… in Nature Communications (2020)

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