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Article
Open AccessUnraveling the connections between gut microbiota, stress, and quality of life for holistic care in newly diagnosed breast cancer patients
There is little research about the stress, quality of life (QOL) and gut microbiota in newly diagnosed breast cancer patients. In this study addressing the dearth of research on stress, quality of life (QOL), ...
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Article
Open AccessEfficacy and safety of combined targeted therapy and immunotherapy versus targeted monotherapy in unresectable hepatocellular carcinoma: a systematic review and meta-analysis
Cancer therapy has evolved from non-specific cytotoxic agents to a selective, mechanism-based approach that includes targeted agents and immunotherapy. Although the response to targeted therapies for unresecta...
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Article
Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief
Many epigenetic regulators are involved in pain-associated spinal plasticity. Coactivator-associated arginine methyltransferase 1 (CARM1), an epigenetic regulator of histone arginine methylation, is a highly i...
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Article
Open AccessA Novel Prediction Model for Bloodstream Infections in Hepatobiliary–Pancreatic Surgery Patients
Bloodstream infections (BSI) are an important source of postoperative mortality in hepatobiliary–pancreatic surgery (HBPS) patients, and no prediction model has been analyzed before.
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Article
Expression of serine peptidase inhibitor Kunitz type 1 in differentiated thyroid cancer
SPINT1, also known as HAI-1, is a Kunitz-type serine protease inhibitor that inhibits multiple proteases including hepatocyte growth factor (HGF) activator and matriptase. SPINT1 has been shown to modulate HGF...
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Article
Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer
Age is an important prognostic factor for papillary thyroid cancer (PTC). However, little is known about why advanced age is associated with poor prognosis. The study investigated the changes in transcription...
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Article
The Long-Term Effects of Mindfulness Added to Family Resilience-Oriented Couples Support Group on Psychological Well-Being and Cortisol Responses in Breast Cancer Survivors and Their Partners
The practice of mindfulness has not been well-developed for cancer survivors and their partners, and its effects on relational well-being and cortisol responses are unknown. This 14-month study aimed to examin...
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Article
Effect of perioperative dexamethasone on subjective voice quality after thyroidectomy: a meta-analysis and systematic review
Prophylactic dexamethasone has been shown to reduce postoperative pain, nausea, and vomiting in patients undergoing thyroidectomy. However, its effects on postoperative voice outcomes remain uncertain.
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Article
Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor
The nuclear receptor farnesoid X receptor (FXR) regulates pathways in lipid, glucose, and energy metabolism. Activation of FXR in mice significantly improved high-fat diet-induced hepatic steatosis. It has bee...
