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Article
Open AccessDevelopment of high-growth influenza H7N9 prepandemic candidate vaccine viruses in suspension MDCK cells
Influenza vaccine manufacturers traditionally use egg-derived candidate vaccine viruses (CVVs) to produce high-yield influenza viruses for seasonal or pandemic vaccines; however, these egg-derived CVVs need an...
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Article
Open AccessNewborn screening for Morquio disease and other lysosomal storage diseases: results from the 8-plex assay for 70,000 newborns
The necessity of early treatment for lysosomal storage diseases (LSDs) has triggered the development of newborn screening for LSDs in recent years. Here we report the first 70,000 newborns screened for Mucopol...
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Article
Open AccessProcess development for pandemic influenza VLP vaccine production using a baculovirus expression system
Influenza viruses cause hundreds of thousands of respiratory diseases worldwide each year, and vaccination is considered the most effective approach for preventing influenza annual epidemics or pandemics. Sinc...
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Article
Open AccessNewborn screening for citrin deficiency and carnitine uptake defect using second-tier molecular tests
Tandem mass spectrometry (MS/MS) analysis is a powerful tool for newborn screening, and many rare inborn errors of metabolism are currently screened using MS/MS. However, the sensitivity of MS/MS screening for...
