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  1. No Access

    Article

    Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

    Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-1...

    Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau… in Nature Immunology (2021)

  2. No Access

    Article

    Loss of translation: a stealth weapon against pathogens?

    Various receptors alert cells to microbial invasion through the detection of conserved molecular patterns and initiate innate immunity. During infection with Legionella pneumophila, macrophages modulate cytokine ...

    Philippe Pierre, Evelina Gatti in Nature Immunology (2013)

  3. Article

    Open Access

    DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells

    The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell...

    Duccio Cavalieri, Damariz Rivero, Luca Beltrame, Sonja I Buschow… in Immunome Research (2010)

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  4. Article

    Open Access

    Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS

    Dendritic cells (DCs) are the sentinels of the mammalian immune system, characterized by a complex maturation process driven by pathogen detection. Although multiple studies have described the analysis of acti...

    Maurizio Ceppi, Giovanna Clavarino, Evelina Gatti, Enrico K Schmidt… in Immunome Research (2009)

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  5. No Access

    Protocol

    Genetic Modification of Murine Dendritic Cells by RNA Transfection

    The ability to manipulate in vitro cultured dendritic cells (DCs) by transfection represents an attractive strategy to load these antigen-presenting cells with genetic material encoding various immunogenic epi...

    Maurizio Ceppi, Enrico Schmidt, Philippe Pierre in Macrophages and Dendritic Cells (2009)

  6. No Access

    Protocol

    Purification and Characterization of MHC Class II Containing Organelles in Mouse Bone-Marrow-Derived Dendritic Cells

    The initiation and propagation of the immune responses is dependent on the ability of antigen-presenting cells (APC) to convert proteins into peptides, to load them intracellularly onto major histocompatibilit...

    Philippe Pierre in Dendritic Cell Protocols (2001)