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  1. No Access

    Article

    Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

    Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin (IL)-1...

    Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau… in Nature Immunology (2021)

  2. No Access

    Article

    Loss of translation: a stealth weapon against pathogens?

    Various receptors alert cells to microbial invasion through the detection of conserved molecular patterns and initiate innate immunity. During infection with Legionella pneumophila, macrophages modulate cytokine ...

    Philippe Pierre, Evelina Gatti in Nature Immunology (2013)

  3. No Access

    Article

    Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

    Phosphorylation of the eukaryotic initiation factor 2 α subunit (eIF2α) is increased in the brains of Alzheimer's disease patients and model mice. Here the authors show that knocking down two kinases that phos...

    Tao Ma, Mimi A Trinh, Alyse J Wexler, Clarisse Bourbon… in Nature Neuroscience (2013)