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  1. No Access

    Article

    Exploring the genetic overlap between twelve psychiatric disorders

    The widespread comorbidity among psychiatric disorders demonstrated in epidemiological studies1–5 is mirrored by non-zero, positive genetic correlations from large-scale genetic studies6–10. To identify shared bi...

    Cato Romero, Josefin Werme, Philip R. Jansen, Joel Gelernter… in Nature Genetics (2022)

  2. No Access

    Article

    Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associa...

    Kyoko Watanabe, Philip R. Jansen, Jeanne E. Savage, Priyanka Nandakumar… in Nature Genetics (2022)

  3. No Access

    Article

    Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

    Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. ...

    Philip R. Jansen, Kyoko Watanabe, Sven Stringer, Nathan Skene… in Nature Genetics (2019)

  4. No Access

    Article

    Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

    Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene ...

    Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, David M. Brazel, Fang Chen… in Nature Genetics (2019)

  5. No Access

    Article

    Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

    Neuroticism is an important risk factor for psychiatric traits, including depression1, anxiety2,3, and schizophrenia4–6. At the time of analysis, previous genome-wide association studies7–12 (GWAS) reported 16 ge...

    Mats Nagel, Philip R. Jansen, Sven Stringer, Kyoko Watanabe… in Nature Genetics (2018)

  6. No Access

    Article

    Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

    Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3–7, but much about i...

    Jeanne E. Savage, Philip R. Jansen, Sven Stringer, Kyoko Watanabe… in Nature Genetics (2018)

  7. Article

    Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

    Nat. Genet.; doi:10.1038/ng.3869; corrected online 31 May 2017 In the version of this article initially published online, heritability was misspelled in the penultimate sentence of the abstract. The error has ...

    Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen… in Nature Genetics (2017)

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    Article

    Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

    Danielle Posthuma and colleagues perform a large meta-analysis for intelligence and determine genetic overlap with several neuropsychiatric and metabolic traits. They find 15 new significant loci and implicate...

    Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen… in Nature Genetics (2017)