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Article
Combination therapy for kidney disease in people with diabetes mellitus
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear causes of kidney injury, occurs in approximately 20–40% of patients with diabetes mellitu...
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Article
Trajectories of eGFR and risk of albuminuria in youth with type 2 diabetes: results from the TODAY cohort study
We conducted exploratory analyses to identify distinct trajectories of estimated glomerular filtration rate (eGFR) and their relationship with hyperfiltration, subsequent rapid eGFR decline, and albuminuria in...
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Article
Kidney Considerations in Pediatric Obesity
Chronic kidney disease (CKD) is a common condition and a major cause of morbidity and mortality in adults, but children and adolescents are also at risk for early kidney injury and development of CKD. Obesity ...
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Article
Estimation of glomerular filtration rate in a pediatric population using non-contrast kidney phase contrast magnetic resonance imaging
Glomerular filtration rate (GFR) is a key measure of kidney function but often inaccurately ascertained by serum creatinine and cystatin C in pediatrics. In this pilot trial, we evaluated the relationship betw...
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Article
Youth-onset type 2 diabetes mellitus: an urgent challenge
The incidence and prevalence of youth-onset type 2 diabetes mellitus (T2DM) and its complications are increasing worldwide. Youth-onset T2DM has been reported in all racial and ethnic groups, but Indigenous pe...
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Article
Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes
We compared plasma metabolites of amino acid oxidation and the tricarboxylic acid (TCA) cycle in youth with and without type 1 diabetes mellitus (T1DM) and related the metabolites to glomerular filtration rate...
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Article
Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes
Early identification of youth with type 1 diabetes (T1D) at risk for diabetic kidney disease may improve clinical outcomes. We examined the cross-sectional relationship between kidney biomarkers neutrophil gel...
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Article
Early microvascular complications in type 1 and type 2 diabetes: recent developments and updates
The prevalence of youth-onset diabetes is progressing rapidly worldwide, and poor glycemic control, in combination with prolonged diabetes duration and comorbidities including hypertension, has led to the earl...
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Article
Open AccessNephroprotective effects of GLP-1 receptor agonists: where do we stand?
Glucagon-like peptide (GLP)-1 receptor agonists are the cornerstone in the treatment of hyperglycemia in many people suffering from type 2 diabetes (T2D). These drugs have potent glucose-lowering actions and, ...
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Article
Asymptomatic hyperuricaemia: a silent activator of the innate immune system
Asymptomatic hyperuricaemia affects ~20% of the general population in the USA, with variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered a benign laboratory finding with ...
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Chapter
Insulin Resistance and the Kidney in Youth
Diabetic kidney disease (DKD) remains a leading cause of end-stage renal disease (ESRD) and mortality in the Western world. Early DKD, including albuminuria and hyperfiltration, are common in adolescents with ...
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Chapter
Diabetic Nephropathy in Children and Adolescents
Diabetic nephropathy remains the leading cause of end-stage renal disease (ESRD) and dialysis in the Western world and a major risk factor for cardiovascular disease (CVD) and mortality. Early phenotypes of DN...
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Article
Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review
Insulin resistance (IR) is recognized to play an important role in the pathogenesis of dyslipidemia. This review summarizes the complex interplay between IR and dyslipidemia in people with and without diabetes.
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Article
Renal Hyperfiltration in Adolescents with Type 2 Diabetes: Physiology, Sex Differences, and Implications for Diabetic Kidney Disease
Compared to adult-onset type 2 diabetes (T2D), youth with T2D have a more aggressive phenotype with greater insulin resistance (IR), more rapid β cell decline, and higher prevalence of diabetic kidney disease ...
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Article
Hyperfiltration and uricosuria in adolescents with type 1 diabetes
Urine uric acid (UUA) has been implicated in the pathogenesis of diabetic nephropathy via its effect on tubular cells. We hypothesized that the UUA level would be higher in adolescents with type 1 diabetes (T1...
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Article
Measuring glomerular filtration rate by iohexol clearance on filter paper is feasible in adolescents with type 1 diabetes in the ambulatory setting
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Article
Diabetic Kidney Disease in Adolescents With Type 2 Diabetes: New Insights and Potential Therapies
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) and dialysis in the Western world. Early DKD, including microalbuminuria and renal hyperfiltration, is common in adolescents...
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Article
Fructose and uric acid in diabetic nephropathy
Clinical studies have reported associations between serum uric acid levels and the development of diabetic nephropathy, but the underlying mechanisms remain elusive. There is evidence from animal studies that ...
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Article
Update on Estimation of Kidney Function in Diabetic Kidney Disease
The American Diabetes Association recommends annual assessment of glomerular filtration rate (GFR) to screen for diabetic nephropathy. GFR is measured indirectly using markers that, ideally, are eliminated onl...
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Article
Association of apolipoprotein B, LDL-C and vascular stiffness in adolescents with type 1 diabetes
LDL cholesterol (LDL-C) is the current lipid standard for cardiovascular disease (CVD)-risk assessment in type 1 diabetes. Apolipoprotein B (apoB) may be helpful to further stratify CVD risk. We explored the a...
