-
Article
Open AccessNeutrophil to lymphocyte ratio (NTLR) predicts local control and overall survival after stereotactic body radiotherapy (SBRT) in metastatic sarcoma
The neutrophil to lymphocyte ratio (NTLR) and absolute lymphocyte count (ALC) recovery are prognostic across many cancers. We investigated whether NLTR predicts SBRT success or survival in a metastatic sarcoma...
-
Chapter
Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease
Osteosarcoma relapses not only herald a very poor prognosis but also opportunities to treat this genetically diverse complex cancer in new ways. This review will attempt to show that the field is a rapidly evo...
-
Chapter
Radiopharmaceuticals for Treatment of Osteosarcoma
Although trace amounts of radioactivity are routinely used to detect osteosarcoma, the use of larger therapeutic amounts of radiation is often an unrecognized opportunity to treat metastatic osteosarcoma. This...
-
Article
Influence of Structure and Microstructure on Deformation Localization and Crack Growth in NiTi Shape Memory Alloys
Porous NiTi shape memory alloys have applications in the biomedical and aerospace fields. Recent developments in metal additive manufacturing have made fabrication of near-net-shape porous products with compli...
-
Article
Cardiovascular involvement by osteosarcoma: an analysis of 20 patients
Although hematogenous spread of osteosarcoma is well known, the imaging findings of cardiovascular involvement by osteosarcoma are seldom reported and can be difficult to recognize. The enhanced resolution of ...
-
Chapter
Al-NiTi Metal Matrix Composites for Zero CTE Materials: Fabrication, Design, and Modeling
Al-NiTi composites fabricated via ultrasonic additive manufacturing (UAM) provide a light-weight solution for low thermal expansion applications. It is shown that the thermal expansion of Al 6061 can be reduce...
-
Chapter
Quantized Crystal Plasticity Modeling of Nanocrystalline Metals
A quantized crystal plasticity (QCP) model, which connects emerging deformation physics with the unique mechanical properties of nanocrystalline metals, is presented in this chapter. The QCP model adopts a dis...
-
Article
Deformation Mechanisms in NiTi-Al Composites Fabricated by Ultrasonic Additive Manufacturing
Thermally active NiTi shape memory alloy (SMA) fibers can be used to tune or tailor the effective coefficient of thermal expansion (CTE) of a metallic matrix composite. In this paper, a novel NiTi-Al composite...
-
Chapter
Mechanical Properties of Nanostructured Metals
This chapter has two principal sections. The first addresses single-phase polycrystalline metals and alloys and the second addresses two-phase multilayered thin films comprised of alternating A-B layers. In th...
-
Article
Simulating Thermal Cycling and Isothermal Deformation Response of Polycrystalline NiTi
A microstructure-based FEM model that couples crystal plasticity, crystallographic descriptions of the B2-B19′ martensitic phase transformation, and anisotropic elasticity is used to simulate thermal cycling a...
-
Article
Critical Strengths for Slip Events in Nanocrystalline Metals: Predictions of Quantized Crystal Plasticity Simulations
This article studies how the monotonic and cyclic stress-strain response of nanocrystalline (NC) metals is affected by the grain-to-grain distribution of critical strengths (τ ...
-
Article
Peak/Plateau Strength in Nanoscale Multilayer Thin Films: Constrained vs Unconstrained Dislocation Nucleation
The peak/plateau strength of multilayer thin films is analyzed in terms of the stress to bow out a dislocation loop from an interface. Comparison of approximate analytic models to experimental data suggests th...
-
Article
Thermal Grooving in Single versus Multilayer Thin Films
A 2D analytic result is presented for the penetration distance P of grain boundary grooves as a function of time t during heating and straining of polycrystalline multilayer thin films with immiscible phases. The...
-
Article
Ewing’s sarcoma of the humerus mimicking fibrous dysplasia on imaging and biological behavior
We present the case of a 12-year-old girl who presented with a pathological fracture through a benign-appearing osteolytic lesion that was presumed to represent fibrous dysplasia. The fracture healed, and over...
-
Article
Correlation of stress state and nanohardness via heat treatment of nickel-aluminide multilayer thin films
Heat treatment of γ-Ni(Al)/γ′-Ni3Al multilayer thin films demonstrates that multilayer hardness correlates with the magnitude of biaxial stress in alternating layers. Films with a columnar grain morphology and (0...
-
Article
Dislocation Confinement and Ultimate Strength in Nanoscale Metallic Multilayers
In nanostructured metallic multilayers, hardness and strength are greatly enhanced compared to their microstructured counterparts. As layer thickness is decreased, three different regions are frequently observ...
-
Article
Dislocation Confinement and Ultimate Strength in Nanoscale Polycrystals
Nanoscale polycrystalline metals typically exhibit increasing hardness with decreasing grain size down to a critical value on the order of 5 to 30 nm. Below this, a plateau or decrease is often observed. Simil...
-
Article
Design Maps for the Tensile Yield Strength of Nanoscale Metallic Multilayers
Metallic nanolayered composite materials can exhibit yield strengths one and a half to two times that of the constituents from which they are constructed. However, experimental data frequently show that there ...
-
Article
Processing and microstructural characterization of sputter-deposited Ni/Ni3Al multilayered thin films
The crystallographic texture, orientation relationships, coherency stress, and thermal stability of sputter-deposited Ni/Ni3Al multilayered thin films were studied as a function of bilayer period (Λ) as well as p...
-
Chapter
The Critical Shear Stress to Transmit A Peierls Screw Dislocation Across A Non-slip** Interface
The critical resolved shear stress to transmit a screw dislocation through a non-slip** (welded) bimaterial interface is studied as a function of the elastic mismatch across the interface and the nonlinear s...
