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28 Result(s)
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Article
Inching toward cure of acute myeloid leukemia: a summary of the progress made in the last 50 years
Despite some claims to the contrary, I believe substantial progress has been made in the last half century toward cure of acute myeloid leukemia in children and adults. The tried and true mechanism for this pr...
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Book
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Article
Prognostic implications of additional chromosome abnormalities among patients with de novo acute promyelocytic leukemia with t(15;17)
This retrospective study performed by the Eastern Cooperative Oncology Group and the Southwest Oncology Group enrolled 140 acute promyelocytic leukemia (APL) patients with t(15;17) to determine the influence o...
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Article
Detection of a new embryonic antigen (ESA-10) in the blood of patients with cancer: preliminary results in the United States
ESA-10 is an embryonic antigen expressed by tumor cells. A method to detect the antigen in the blood based on alterations in the erythrocyte sedimentation rate that occur when antiserum to ESA-10 is bound to t...
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Article
A pilot study of carboplatin and mitoxantrone in blast crisis of chronic myeloid leukemia
The efficacy and toxicity of carboplatin plus mitoxantrone in blast crisis of chronic myeloid leukemia (CMLBC) were evaluated. Between 1990 and 1996, 20 patients (11 males and nine females, median age of 49 ye...
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Article
Serum globulins as marker of immune restoration after treatment with high-dose rituximab for chronic lymphocytic leukemia
An important biological alteration in chronic lymphocytic leukemia (CLL) is the dysregulation of immunoglobulin production, as a consequence of complex and yet incompletely understood interactions between plas...
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Article
Capecitabine-induced pancolitis
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Article
Phase I trial of infusional cyclophosphamide, doxorubicin, and etoposide plus granulocyte-macrophage colony stimulating factor (GM-CSF) in non-hodgkin’s lymphoma
Purpose: To determine the recommended phase II dose (RPTD) of a 96-h continuous intravenous infusion (CIVI) of cyclophosphamide (200, 300, or 400 mg/m2/d) and etoposide (60 or 90 mg/m2/d)...
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Article
Probable veno-occlusive disease after treatment with gemtuzumab ozogamicin in a patient with acute myeloid leukemia and a history of liver transplantation for familial hemochromatosis
A 69-yr-old male with a history of familial hemochromatosis and status after liver transplantation was found to have severe thrombocytopenia (platelet count of 8000/µL). He was also anemic and was diagnosed wi...
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Article
Phase I trial of fludarabine and paclitaxel in non-hodgkin’s lymphoma
Fludarabine is an active agent in low-grade non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. Paclitaxel is also active in patients with refractory lymphoma, and preclinical data suggest an additive eff...
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Article
Microangiopathic hemolysis refractory to plasmapheresis responding to docetaxel and cisplatin
We report the case of a 56-yr-old woman with adenocarcinoma of unknown origin metastatic to the bone marrow presenting with a thrombotic thrombocytopenic purpura-like syndrome refractory to protracted daily pl...
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Article
Editorial
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Article
Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases
The primary objective of this study was to determine whether caspases are involved in arsenic trioxide(ATO)-induced apoptosis of human myeloid leukemia cells. A secondary objective was to determine whether apo...
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Article
Therapeutic efficacy of theophylline in chronic lymphocytic leukemia
Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells bothin vitro andin vivo. We have treated three advanced CLL p...
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Chapter
Novel biologic approaches to hematologic malignancies
Normal hematopoiesis and lymphopoiesis are dependent upon the interactions of a broad array of endogenous cytokines that have both positive and negative influences on proliferation and differentiation of these...
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Article
Saquinavir enhances the mucosal toxicity of infusional cyclophosphamide, doxorubicin, and etoposide in patients with HIV-associated non-Hodgkin's lymphoma
Protease inhibitors are an important new class of agents for the treatment of human immunodeficiency virus (HIV) infection. The purpose of our trial was to determine the feasibility of combining the protease i...
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Article
Phase II trial of merbarone in patients with malignant brain tumors
The standard treatment for patients with primary malignant glioma includes surgical resection, radiotherapy, and nitrosourea. Despite this multimodality approach, adults with newly diagnosed glioblastoma multi...
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Article
A novel second line chemotherapy treatment of recurrent thymoma
Thymoma is an uncommon malignancy which is initially treated with surgery. Combined modality treatment with radiation and chemotherapy is utilized in cases of unresectable or metastatic disease. In patients wi...
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Article
Therapeutic effect of cyclosporine A in thrombocytopenia after myeloablative chemotherapy in acute myeloid leukaemia
Four patients with acute myelogenous leukaemia (AML), who developed isolated thrombocytopenia after anti-leukaemic chemotherapy, were treated with cyclosporine A and showed significantly enhanced platelet reco...
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Article
Atypical clonal T-cell proliferation in infectious mononucleosis
An atypical case of infectious mononucleosis characterized by fever, acute tonsillitis, and bilateral cervical adenopathy is reported in a previously healthy young man. Although serology was positive for the E...
