58 Result(s)

Article

Occurrence of renal cell carcinoma and hematologic malignancies (predominantly lymphoid) in individuals and in families

The relationship between renal cell cancer (RCC) and hematologic malignancy (HM) in the same individual has been reported for more than 20 years, and is noted in SEER database studies. Family histories suggest...

Janice P. Dutcher, Peter H. Wiernik, Leticia Varella… in Familial Cancer (2016)

Article

Inching toward cure of acute myeloid leukemia: a summary of the progress made in the last 50 years

Despite some claims to the contrary, I believe substantial progress has been made in the last half century toward cure of acute myeloid leukemia in children and adults. The tried and true mechanism for this pr...

Peter H. Wiernik in Medical Oncology (2014)

Article

Prognostic implications of additional chromosome abnormalities among patients with de novo acute promyelocytic leukemia with t(15;17)

This retrospective study performed by the Eastern Cooperative Oncology Group and the Southwest Oncology Group enrolled 140 acute promyelocytic leukemia (APL) patients with t(15;17) to determine the influence o...

Peter H. Wiernik, Zhuoxin Sun, Holly Gundacker, Gordon Dewald… in Medical Oncology (2012)

Article

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

The authors apply reverse engineering of transcriptional networks to identify the main functional drivers of the pro-leukemic transcriptional activity of TLX1 and TLX3, transcription factors usually altered in...

Giusy Della Gatta, Teresa Palomero, Arianne Perez-Garcia… in Nature Medicine (2012)

Article

Detection of a new embryonic antigen (ESA-10) in the blood of patients with cancer: preliminary results in the United States

ESA-10 is an embryonic antigen expressed by tumor cells. A method to detect the antigen in the blood based on alterations in the erythrocyte sedimentation rate that occur when antiserum to ESA-10 is bound to t...

Peter H. Wiernik, Dahlia Elkadi, Alvaro Luongo-Cespedes… in Medical Oncology (2011)

Article

The TLX1 oncogene drives aneuploidy in T cell transformation

The oncogenic activation of TLX transcription factors demarcates a specific molecular subtype of T cell acute lymphoblastic leukemia (T-ALL). This study identifies aneuploidy induction as a molecular mechanism...

Kim De Keersmaecker, Pedro J Real, Giusy Della Gatta, Teresa Palomero… in Nature Medicine (2010)

Article

A pilot study of carboplatin and mitoxantrone in blast crisis of chronic myeloid leukemia

The efficacy and toxicity of carboplatin plus mitoxantrone in blast crisis of chronic myeloid leukemia (CMLBC) were evaluated. Between 1990 and 1996, 20 patients (11 males and nine females, median age of 49 ye...

Janice P. Dutcher, Evelyn L. Morris, Bruce Gaynor, Elisabeth Paietta… in Medical Oncology (2010)

Article

PHF6 mutations in T-cell acute lymphoblastic leukemia

Adolfo Ferrando and colleagues identify frequent inactivating mutations and deletions in the X chromosome gene PHF6 in T-cell acute lymphoblastic leukemia. PHF6 mutations are found almost exclusively in males and...

Pieter Van Vlierberghe, Teresa Palomero, Hossein Khiabanian… in Nature Genetics (2010)

Article

Serum globulins as marker of immune restoration after treatment with high-dose rituximab for chronic lymphocytic leukemia

An important biological alteration in chronic lymphocytic leukemia (CLL) is the dysregulation of immunoglobulin production, as a consequence of complex and yet incompletely understood interactions between plas...

Doru T. Alexandrescu, Peter H. Wiernik in Medical Oncology (2008)

Article

Capecitabine-induced pancolitis

Doru T. Alexandrescu, Janice P. Dutcher… in International Journal of Colorectal Disease (2007)

Article

Phase I trial of infusional cyclophosphamide, doxorubicin, and etoposide plus granulocyte-macrophage colony stimulating factor (GM-CSF) in non-hodgkin’s lymphoma

Purpose: To determine the recommended phase II dose (RPTD) of a 96-h continuous intravenous infusion (CIVI) of cyclophosphamide (200, 300, or 400 mg/m²/d) and etoposide (60 or 90 mg/m²/d)...

Joseph A. Sparano MD, Abdissa Negassa, Erick Lansigan, Robin Locke… in Medical Oncology (2005)

Article

Intravascular lymphoma associated with hemophagocytic syndrome: a rare but aggressive clinical entity

We report a 55-year-old male with a diagnosis of intravascular lymphoma and hemophagocytosis. He initially presented with hemolytic anemia and splenomegaly and was successfully treated with oral steroids. His ...

Niyati S. Bhagwati, Stanley J. Oiseth, Lool S. Abebe… in Annals of Hematology (2004)

Article

Probable veno-occlusive disease after treatment with gemtuzumab ozogamicin in a patient with acute myeloid leukemia and a history of liver transplantation for familial hemochromatosis

A 69-yr-old male with a history of familial hemochromatosis and status after liver transplantation was found to have severe thrombocytopenia (platelet count of 8000/µL). He was also anemic and was diagnosed wi...

Kevin P. O’Boyle, Ashwin Murigeppa, Dharamvir Jain, Leonard Dauber… in Medical Oncology (2003)

Article

Phase I trial of fludarabine and paclitaxel in non-hodgkin’s lymphoma

Fludarabine is an active agent in low-grade non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. Paclitaxel is also active in patients with refractory lymphoma, and preclinical data suggest an additive eff...

Muhammad R. Abbasi M.D., Joseph A. Sparano, Catherine Sarta… in Medical Oncology (2003)

Article

Microangiopathic hemolysis refractory to plasmapheresis responding to docetaxel and cisplatin

We report the case of a 56-yr-old woman with adenocarcinoma of unknown origin metastatic to the bone marrow presenting with a thrombotic thrombocytopenic purpura-like syndrome refractory to protracted daily pl...

George Marcoullis, Lool Abebe, Dharamvir Jain, Richard Talusan… in Medical Oncology (2002)

Article

N-Methylformamide in Advanced Squamous Cancer of the Uterine Cervix: An Eastern Cooperative Oncology Group Phase II Trial

Purpose: Preclinical and clinical data support the studyof polar-planar compounds such as N-Methylformamide (NMF) inadvanced squamous cell carcinoma of the uterine cervix (SCC).This phase II trial sought to dete...

Lakshmi Rajdev, Zi-Fan Yu, Scott Wadler, Edie Weller… in Investigational New Drugs (2001)

Article

Toxicity and Response Evaluation of the Interferon Inducer Poly ICLC Administered at Low Dose in Advanced Renal Carcinoma and Relapsed or Refractory Lymphoma: A Report of Two Clinical Trials of the Eastern Cooperative Oncology Group

Purpose: Phase II studies were conducted toevaluate the safety and efficacy of the interferon inducerPoly ICLC at low doses in advanced renal cancer and relapsedor refractory lymphoma. Patients and methods:Twent...

Bruce J. Giantonio, Howard Hochster, Ronald Blum… in Investigational New Drugs (2001)