3 Result(s)
within
Peter A. Galie
Neurosciences
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Article
Open AccessTranscriptomic analysis of a 3D blood–brain barrier model exposed to disturbed fluid flow
Cerebral aneurysms are more likely to form at bifurcations in the vasculature, where disturbed fluid is prevalent due to flow separation at sufficiently high Reynolds numbers. While previous studies have demon...
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Article
Open AccessRecombinant human plasma gelsolin reverses increased permeability of the blood–brain barrier induced by the spike protein of the SARS-CoV-2 virus
Plasma gelsolin (pGSN) is an important part of the blood actin buffer that prevents negative consequences of possible F-actin deposition in the microcirculation and has various functions during host immune res...
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Article
SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation
The SARS-CoV-2 spike protein has been shown to disrupt blood–brain barrier (BBB) function, but its pathogenic mechanism of action is unknown. Whether angiotensin converting enzyme 2 (ACE2), the viral binding s...
