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Article
Open AccessDetection and classification of the integrative conjugative elements of Lactococcus lactis
Lactococcus lactis is widely applied by the dairy industry for the fermentation of milk into products such as cheese. Adaptation of L. lactis to the dairy environment often depends on functions encoded by mobile...
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Article
Open AccessA citizen-science-enabled catalogue of the vaginal microbiome and associated factors
Understanding the composition and function of the vaginal microbiome is crucial for reproductive and overall health. Here we established the Isala citizen-science project to analyse the vaginal microbiomes of ...
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Article
Open AccessFunctional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial
Oral microbial therapy has been studied as an intervention for a range of gastrointestinal disorders. Though research suggests that microbial exposure may affect the gastrointestinal system, motility, and host...
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Article
Open AccessThe effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
The aim of this study was to investigate the effects of three Lactobacillus plantarum strains on in-vivo small intestinal barrier function and gut mucosal gene transcription in human subjects. The strains were se...
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Article
Open AccessUse of non-growing Lactococcus lactis cell suspensions for production of volatile metabolites with direct relevance for flavour formation during dairy fermentations
Lactococcus lactis is a lactic acid bacterium that has been used for centuries in the production of a variety of cheeses, as these bacteria rapidly acidify milk and greatly contribute to the flavour of the ferme...
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Article
Open AccessFermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness
Lactococcus lactis is industrially employed to manufacture various fermented dairy products. The most cost-effective method for the preservation of L. lactis starter cultures is spray drying, but during this pro...
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Article
Open AccessTranscriptome signatures of class I and III stress response deregulation in Lactobacillus plantarum reveal pleiotropic adaptation
To cope with environmental challenges bacteria possess sophisticated defense mechanisms that involve stress-induced adaptive responses. The canonical stress regulators CtsR and HrcA play a central role in the ...
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Article
Open AccessImpact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling
Bacterial cell surface-associated polysaccharides are involved in the interactions of bacteria with their environment and play an important role in the communication between pathogenic bacteria and their host ...
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Article
Open AccessIdentification of key peptidoglycan hydrolases for morphogenesis, autolysis, and peptidoglycan composition of Lactobacillus plantarum WCFS1
Lactobacillus plantarum is commonly used in industrial fermentation processes. Selected strains are also marketed as probiotics for their health beneficial effects. Although the functional role of peptidoglycan-d...
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Article
Open AccessLactobacillus plantarum possesses the capability for wall teichoic acid backbone alditol switching
Specific strains of Lactobacillus plantarum are marketed as health-promoting probiotics. The role and interplay of cell-wall compounds like wall- and lipo-teichoic acids (WTA and LTA) in bacterial physiology and ...
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Article
Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa
Probiotics are defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host” and have been studied by the sc...
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Engineering Robust Lactic Acid Bacteria
For centuries, lactic acid bacteria (LAB) have been industrially exploited as starter cultures in the fermentation of foods and feeds for their spoilage-preventing and flavor-enhancing characteristics. More re...
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Article
Open AccessIdentification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells
Modulation of the immune system is one of the most plausible mechanisms underlying the beneficial effects of probiotic bacteria on human health. Presently, the specific probiotic cell products responsible for ...
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Article
Open AccessThioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1
Thioredoxin (TRX) is a powerful disulfide oxido-reductase that catalyzes a wide spectrum of redox reactions in the cell. The aim of this study is to elucidate the role of the TRX system in the oxidative stress...
