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  1. Article

    Open Access

    Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study

    Studies investigating associations between kynurenines and cognitive function have generally been small, restricted to clinical samples or have found inconsistent results, and associations in the general adult...

    Lieke Bakker, Inez H. G. B. Ramakers, Martin P. J. van Boxtel… in Diabetologia (2021)

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  2. Article

    Open Access

    The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease

    The tryptophan metabolite kynurenine has potent immune modulatory and vasoactive properties. Experimental data implicate kynurenine in obesity-related morbidities. Epidemiological studies are, however, sparse....

    Eirik W. Rebnord, Elin Strand, Øivind Midttun, Gard F.T. Svingen… in Diabetologia (2017)

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  3. No Access

    Article

    Functional inference of the methylenetetrahydrofolate reductase 677 C > T and 1298A > C polymorphisms from a large-scale epidemiological study

    Two functional single nucleotide polymorphisms, 677C > T and 1298A > C have been described for the methylenetetrahydrofolate (MTHFR) gene. Both are associated with reduced enzyme activity in vitro. For the 677...

    Arve Ulvik, Per M. Ueland, Åse Fredriksen, Klaus Meyer… in Human Genetics (2007)