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Article
Polydopamine‐based surface functionalization of watermelon rind as a 3D nanofibrous cellulose scaffold for osteogenesis
In this study, we investigated the osteogenic potential of a low cost, sustainable cellulosic scaffold made from decellularized water-melon rind (dWMR). The dWMR scaffold was later surface treated with polydop...
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Article
Nintedanib Alleviates Chronic Pancreatitis by Inhibiting the Activation of Pancreatic Stellate Cells via the JAK/STAT3 and ERK1/2 Pathways
Nintedanib (Ninte) has been approved for the treatment of pulmonary fibrosis, and whether it can ameliorate chronic pancreatitis (CP) is unknown.
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Article
Is a Distal Resection Margin of ≤ 1 cm Safe in Patients with Intermediate- to Low-Lying Rectal Cancer? A Systematic Review and Meta-Analysis
It is generally accepted that the distal resection margin of intermediate- to low-lying rectal cancer should be greater than 2 cm and at least 1 cm in special cases. This study intends to investigate whether a...
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Article
The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway
The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Ant...
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Article
Open AccessVapor-phased fabrication and modulation of cell-laden scaffolding materials
Bottom–up approaches using building blocks of modules to fabricate scaffolds for tissue engineering applications have enabled the fabrication of structurally complex and multifunctional materials allowing for ...
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Article
Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system provides a groundbreaking genetic technology that allows scientists to modify genes by targeting specific g...
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Article
Microencapsulation and Antimicrobial Activity of Plant Essential Oil Against Ralstonia solanacearum
Ralstonia solanacearum is a common plant bacterium, and the improper use of chemicals to control this bacterium is harmful to the environment. Many undeveloped aromatic plants and green plant waste can be used fo...
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Article
Open AccessEstrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression
Gender differences in fatigue manifest as females being more prone to feel exhaustion and having lower muscle endurance. However, the mechanisms of these effects remain unclear. We investigated whether orosomu...
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Chapter
New Combination/Application of Polymer-Based Nanoparticles for Biomedical Engineering
Polymer-based nanoparticles (PNPs) are attractive in part due to their ultra-small size, versatility and target specificity. Therefore, PNPs have been increasingly used in a variety of biomedical applications ...
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Article
Open AccessMuscle fatigue: general understanding and treatment
Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and de...
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Article
Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3
Although it is generally believed that nicotine accounts for the beneficial effect of smoking on ulcerative colitis, the underlying mechanisms remain not well understood. Our previous finding that nicotine inh...
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Article
Open AccessBinary colloidal crystals (BCCs) as a feeder-free system to generate human induced pluripotent stem cells (hiPSCs)
Human induced pluripotent stem cells (hiPSCs) are capable of differentiating into any cell type and provide significant advances to cell therapy and regenerative medicine. However, the current protocol for hiP...
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Article
MicroRNA-124 negatively regulates LPS-induced TNF-α production in mouse macrophages by decreasing protein stability
MicroRNAs play pivotal roles in regulation of both innate and adaptive immune responses. In the present study, we investigated the effects of microRNA-124 (miR-124) on production of the pro-inflammatory cytoki...
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Article
Open AccessTargeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3
The human cervical cancer oncogene (HCCR) has been found to be overexpressed in a variety of human cancers. However, the level of expression of HCCR and its biological function in gastric cancer are largely un...
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Article
Protective effect of hydrogen sulfide on TNF-α and IFN-γ-induced injury of intestinal epithelial barrier function in Caco-2 monolayers
Studies have verified the protective effect of Hydrogen Sulfide (H2S) on gastric ulcer and ulcerative colitis, but the mechanisms are not fully illustrated. In this study, the possible protective effect of H2S on...
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Article
Protective Effect of 1,25-Dihydroxyvitamin D3 on Lipopolysaccharide-Induced Intestinal Epithelial Tight Junction Injury in Caco-2 Cell Monolayers
Lipopolysaccharide was found to be elevated in the plasma of necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD) patients and may play an important role in the pathogenesis and propagation of ...
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Chapter
Manufacture of Chemically Modified Antibacterial Surfaces
It is well-known that the prevention of biofilm formation on medical implants is a highly desirable outcome for world-wide patient care. The lack of new antibiotic discoveries and the build-up of resistance to...
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Article
Open AccessAberrant methylation of the SPARC gene promoter and its clinical implication in gastric cancer
Secreted protein acidic and rich in cysteine (SPARC) gene has been shown to be epigenetically silenced in several cancers. We investigated the loss of expression and promoter methylation of this tumor suppressor ...
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Article
Open AccessArdipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells
Ardisia pusilla A. DC., family Myrsinaceae, is a traditional Chinese medicine named Jiu Jie Long with a variety of pharmacological functions including anti-cancer activities. In this study, we purified a natural...
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Article
Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription
Barrier function is essential for the maintenance of normal intestinal function. Dysregulation of the intestinal barrier underlies a wide range of disorders.
