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  1. No Access

    Article

    PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway

    This study aimed at investigating the role of the proprotein convertase subtilisin/Kexin type 9 (PCSK9)-mediated autophagy on myocardial ischemia/reperfusion injury (MIRI). To determine the relationship betwee...

    Guangwei Huang, Hailong Bao, Peng Zhan, **yang Lu… in Molecular & Cellular Toxicology (2024)

  2. No Access

    Article

    Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes

    Osteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identifying mechanisms and biomarkers of osteoporosis will enable the development of preventa...

    Dongfeng Chen, Ying Li, Qiang Wang, Peng Zhan in Calcified Tissue International (2023)

  3. Article

    Open Access

    SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules

    As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread. The nucleic acid-induced stress response is an essenti...

    Yi Zheng, Jian Deng, Lulu Han, Meng-Wei Zhuang… in Signal Transduction and Targeted Therapy (2022)

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  4. Article

    Open Access

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

    Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread worldwide and has affected more than 10 million individuals. A typical feature of...

    Yi Zheng, Meng-Wei Zhuang, Lulu Han, **g Zhang… in Signal Transduction and Targeted Therapy (2020)

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  5. Article

    Open Access

    Targeting the entry step of SARS-CoV-2: a promising therapeutic approach

    **g Li, Peng Zhan, **nyong Liu in Signal Transduction and Targeted Therapy (2020)

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  6. Article

    Open Access

    Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways

    Human adipose stem cells (ASCs) have emerged as a promising treatment paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of stem cells is partially mediated by extracellular vesicle...

    Sen Ren, **g Chen, Dominik Duscher, Yutian Liu, Guojun Guo… in Stem Cell Research & Therapy (2019)

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