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Article
PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway
This study aimed at investigating the role of the proprotein convertase subtilisin/Kexin type 9 (PCSK9)-mediated autophagy on myocardial ischemia/reperfusion injury (MIRI). To determine the relationship betwee...
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Article
Current collapse suppressed GaN diodes with 38 Watts high RF power rectifier capability
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Article
Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes
Osteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identifying mechanisms and biomarkers of osteoporosis will enable the development of preventa...
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Article
Open AccessBulk-local-density-of-state correspondence in topological insulators
In the quest to connect bulk topological quantum numbers to measurable parameters in real materials, current established approaches often necessitate specific conditions, limiting their applicability. Here we ...
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Article
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy
Hypertensive nephropathy (HTN) ranks as the second-leading cause of end-stage renal disease (ESRD). Accumulating evidence suggests that persistent hypertension injures tubular cells, leading to tubulointerstit...
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Article
Open AccessDiscovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the c...
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Chapter
Public Pensions and Income Transfer Between the Elderly and Their Children
Using data from the China Health and Retirement Longitudinal Survey of 2013 and 2015, this study investigates the effect of enrollment in public pensions and the amount of public pension benefits on the income...
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Chapter
Towards a Universal Chinese Future Public Pension Structure: Re-engineering the Social Pension Scheme to Become a Guarantee in the Earnings-Related Pension Scheme
This study investigates how to encourage the 53% (at the end of 2021) of the total insurees presently covered by China's Social Pension (SP) scheme to voluntarily join the Earnings-Related Pension (EP) scheme ...
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Article
Cellulase immobilized onto amino-functionalized magnetic Fe3O4@SiO2 nanoparticle for poplar deconstruction
A two-step synthesis method was successfully applied to covalently immobilize cellulase Cellic CTec2 onto silicon dioxide-coated functionalized magnetic nano-Fe3O4 particle (Fe3O4@SiO2). The optimized immobilizat...
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Article
Open AccessSARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread. The nucleic acid-induced stress response is an essenti...
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Article
Identifiable Temporal Feature Selection via Horizontal Visibility Graph Towards Smart Medical Applications
With the proliferation of IoMT (Internet of Medical Things), billions of connected medical devices are constantly producing oceans of time series sensor data, dubbed as time series for short. Considering these...
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Article
Efficient continuous KNN join processing for real-time recommendation
Along with the sustainable and rapid accumulation of user-generated contents in social networking websites, how to push a certain content to the corresponding interested users, named recommendation for short, ...
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Article
Open AccessHazard assessment of oil spills along the main ship** lane in the Red Sea
This study investigates the risk from oil spills along the main ship** lane in the Red Sea based upon oil spill model trajectories forced by the outputs of validated high resolution regional met-ocean data. ...
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Article
Temporal anomaly detection on IIoT-enabled manufacturing
Along with the coming of industry 4.0 era, industrial internet of things (IIoT) plays a vital role in advanced manufacturing. It can not only connect all equipment and applications in manufacturing processes c...
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Article
Higher-order band topology
A conventional topological insulator (TI) has gapped bulk states but gapless edge states. The emergence of the gapless edge states is dictated by the bulk topological invariant of the insulator and the preserv...
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Article
Open AccessThe development of an effective synthetic route of rilpivirine
Rilpivirine (RPV) was approved by the U.S. FDA (Food and Drug Administration) in 2011 to treat individuals infected with human immunodeficiency virus 1 (HIV-1). Significantly, rilpivirine is three fold more po...
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Article
Temporal representation learning for time series classification
Recent years have witnessed the exponential growth of time series data as the popularity of sensing devices and development of IoT techniques; time series classification has been considered as one of the most ...
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Article
SPAR: set-based piecewise aggregate representation for time series anomaly detection
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Chapter
HIV-1 and HBV RNase H as Metal-Chelating Inhibitors: Discovery and Medicinal Chemistry Strategies
highly pathogenic reverse-transcribing viruses. Despite significant progress achieved so far , the currently available treatments are difficulty to eradicate latent viral reservoirs due to severe side ef...
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Chapter
Pension Benefit Inequality of the Elderly in China
Using the data from the 2013 Chinese Household Income Survey (CHIPs2013), this chapter investigates the inequality of pension benefit among the elderly who should receive pension benefit. It is found that ther...
