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Article
Open AccessThe phylodynamics of SARS-CoV-2 during 2020 in Finland
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of infections and fatalities globally since its emergence in late 2019. The virus was first detected in Finland in January 2020,...
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Article
Open AccessThe CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants
Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary ...
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Article
Open AccessSomatic mutations in lymphocytes in patients with immune-mediated aplastic anemia
The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In immune-mediated aplastic anemia (AA), cytotoxic T-ce...
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Article
Open AccessAuthor Correction: Clonal hematopoiesis in patients with rheumatoid arthritis
A Correction to this paper has been published: https://doi.org/10.1038/s41408-021-00427-1
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Article
Open AccessExamining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts
High blood pressure (BP) is a major risk factor for many noncommunicable diseases. The effect of mitochondrial DNA single-nucleotide polymorphisms (mtSNPs) on BP is less known than that of nuclear SNPs. We inv...
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Article
Open AccessSomatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
Graft versus host disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient with chronic GvHD (cGvHD) carrying persistent CD4+ T cel...
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Article
Open AccessTaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration
HPV genomic variability and chromosomal integration are important in the HPV-induced carcinogenic process. To uncover these genomic events in an HPV infection, we have developed an innovative and cost-effectiv...
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Article
Open AccessClonal hematopoiesis in patients with rheumatoid arthritis
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Article
Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing
Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exo...
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Article
Open AccessComparison of solution-based exome capture methods for next generation sequencing
Techniques enabling targeted re-sequencing of the protein coding sequences of the human genome on next generation sequencing instruments are of great interest. We conducted a systematic comparison of the solut...
