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Article
Data Format Standardization and DICOM Integration for Hyperpolarized 13C MRI
Hyperpolarized (HP) 13C MRI has shown promise as a valuable modality for in vivo measurements of metabolism and is currently in human trials at 15 research sites worldwide. With this growth, it is important to ad...
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Article
Open AccessRegional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) 13C-pyruvate MRI is a promisi...
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Article
Utilizing the wavelet transform’s structure in compressed sensing
Compressed sensing has empowered quality image reconstruction with fewer data samples than previously thought possible. These techniques rely on a sparsifying linear transformation. The Daubechies wavelet tran...
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Article
Di-chromatic interpolation of magnetic resonance metabolic images
Magnetic resonance imaging with hyperpolarized contrast agents can provide unprecedented in vivo measurements of metabolism, but yields images that are lower resolution than that achieved with proton anatomica...
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Article
Open AccessNon-invasive assessment of telomere maintenance mechanisms in brain tumors
Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use...
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Article
Open Access68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality
In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68Ga-PSMA-11 PET/MRI scans.
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Article
Open AccessHyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study
Hyperpolarized (HP) 13C-pyruvate MRI is a stable-isotope molecular imaging modality that provides real-time assessment of the rate of metabolism through glycolytic pathways in human prostate cancer. Heretofore th...
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Chapter
MR Pulse Sequences for PET/MRI
PET/MRI systems have unique requirements for the MRI scan components, which consist of various MR pulse sequences. These unique requirements include performing whole-body scanning, estimating the photon attenu...
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Article
Ultrashort echo time and zero echo time MRI at 7T
Zero echo time (ZTE) and ultrashort echo time (UTE) pulse sequences for MRI offer unique advantages of being able to detect signal from rapidly decaying short-T2 tissue components. In this paper, we applied 3D...
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Article
Non-invasive in vivo assessment of IDH1 mutational status in glioma
Gain-of-function mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in low-grade gliomas and secondary glioblastoma. They lead to intracellular accumulation of the oncometabolite...
